Clinical Analysis Of Renal Injury By Systemic Lupus Erythematosus

Objective To study the prevalence of kidney damage and the clinical and laboratory characteristics in systemic lupus erythematosus (SLE) patients. To provide clinical data for early diagnosis and treatment, and improve patients'prognosis. Methods A retrospective study was performed to assess the prevalence of kidney damage, clinical manifestations and laboratory data from 895 SLE patients.Results 64.5 percent of the 895 SLE patients had renal damages. Urinary cast, high blood urea nitrogen and creatinine occurred more in male. Patients with circulatory, digestive, respiratory, blood system disorders had a higher risk of kidney damage, with which the circulatory system lesions had the maximum correlation (β= 0.896), while those with skin and arthrosis lesions had a lower risk. Those with positive anti-dsDNA and declined C3 had a higher risk of kidney damage, while those who had positive anti-nRNP risked less.Conclusions The incidence rate of renal damage is very high in SLE patients, and the damage in male seems to be more severe. The disorders of splanchnic systems are closely correlated with renal damage of SLE patients; however, skin and arthrosis diseases do not parallel with it. There is a relationship between some laboratory indexes and renal damage in SLE patients.