| Object: The purpose of this study was to determine whether hemocoagulase injection guided by contrast-enhanced ultrasonography (CEUS) could control active bleeding in rabbit livers.Method: Thirty rabbits were impacted with an 18-gauge semiautomatic biopsy needle to create active bleeding liver models which confirmed with CEUS and randomly divided into two groups: a treatment group (n = 15) and a control group (n = 15). In the treatment group, hemocoagulase was injected into the bleeding site under ultrasonographic guidance. In the control group, the active bleeding site was treated with normal saline. When treatment procedures were performed, lactated Ringer's solution resuscitation was performed in both groups to maintain the mean arterial pressure at 70 mmHg for 1 hour. At the end of the study, we analyzed the intraperitoneal blood loss, mean heart rate and hematocrit value. Result: After hemocoagulase injection, the former bleeding site appeared on CEUS as a devoid of contrast. The lower blood loss in the treatment group than that in the control group(38.0±16.6 versus 107.9±20.8 Ml,P< 0.05). The mean hematocrit value was significantly higher in the treatment group in comparison with the control group(23.9%±3.8% versus 18.8%±4.1%,P< 0.05). The mean hematocrit value and the heart rate were significantly higher in the treatment group in comparison with the control group(23.9%±3.8% versus 18.8%±4.1%; P < 0.05; 250%±18% versus 224%±16%; P < 0.05).Conclusion: Hemocoagulase injection guided by contrast-enhanced ultrasonographically significantly decreased blood loss in active rabbit liver bleeding models. The results of the present study indicate that it is a simple and quick method to control blood loss in active liver bleeding. |
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