Experimental Study Of Effects Of Contrast-enhanced Ultrasound Guided Local Hemostatic Injection Treatment In Hemorrhage Renal Trauma

Objective:To study the short-term effects of contrast-enhanced ultrasound guided hemocoagulase injection therapy in renal trauma models.Methods:25 rabbits were induced asⅢ-Ⅳgrade renal trauma models by puncture. Mean blood pressure was monitored simultaneously and maintained at 70mmHg. Divided them into two groups randomly, percutaneous hemostatic injection treatment in experiment group and percutaneous saline injection treatment in control group were guided by contrast-enhanced ultrasonography. Subcapsular hematomas were assessed by regular Ultrasonography 1h after treatment, and hemorrhage volume was recorded and the specimens of lesion were harvested for histopathology after animal executed.Results:In the control group, though blood clots presented, active bleeding still existed,while the active bleeding was stopped completely in the experiment group. No significance was found in the areas of subcapsular hematomas between 2 groups. The hemorrhage volume of control group was significantly greater than treatment group(76±11ml versus 13±5ml, P<0.05).Conclusion:As the hemocoagulase injection can effectively stop the bleeding in experimental models within a short time, the effects of hemostatic agent could be regarded as a potential clinical treatment in renal trauma.