Study Of Physiological Pharmacokinetics Of Traditional Chinese Medicine Of Curculigo Orchioides Model

1 Research Purpose:Establish the physiological pharmacokinetic model in rats and verified. Provide a scientific basis for scientific guidance athletes medication and the pharmacokinetics of Chinese herbal medicine studies.2 Research Method:After stewing traditional Chinese medicine Xianmao (Curculigo orchioides Gaertn.), we gained its aqueous extract, which was used for intragastric administration on rats (Rattus norregicus). At preset times, their blood and tissues were extracted and after proper treatment, were measured of drug concentration in them employing HPLC method. Physiological pharmacokinetics simulation model was designed on computer applying the software Matlab/Simulink. This model was used to simulate changing Xianmao's concentration in rats' blood and tissues of different time points. Concentration data gained from experiment measurement and concentration data gained from physiological pharmacokinetics simulation model were compared in order to test and verify the effectiveness of the model.3 Research Summary:3.1 It is demonstrated by the fact that the data gained from simulation model fits relatively well to the data gained from experiment measurement that Xianmao's physiological pharmacokinetics simulation model is quite scientifically reasonable, filling up the blank of pharmacokinetics studies on Xianmao, providing scientific basis for pharmacokinetics studies on Xianmao in the future to a certain extent.3.2 Orcinol glucosid which is Xianmao's main composition which can enter blood mainly distributes in rats'blood, hearts, lungs, livers, kidneys, muscles (quadriceps femoris) and other tissues or organs. The concentrations in them from highest to lowest are ranked as:blood, heart, lung, liver, kidney, muscle (quadriceps femoris).3.3 According to pharmacokinetics parameters of Orcinol glucosid, the optimum pharmac okinetics compartment model in rats is single compartment model. The mean time to rea ch peak (Cmax) of it is 120 min. Its half-life period (t1/2) is 69.31min, its absorption h alf-life period (tl/2Ka) being 29.49min.3.4 The process of the drug absorption is omitted in the process of model designing. As a result, the mean time to reach peak (Cmax) in simulation is shorter than it is gained from measurements. So this model need to be further improved and perfected.3.5 In physiological pharmacokinetics simulation models, the main parameter is blood perfusion rate. However, in moving state, body's redistribution of blood leads to evident change in blood perfusion rate, as a result, affecting the practice of the model fundamentally. In conclusion, physiological pharmacokinetics simulation models of anti-fatigue traditional Chinese medicine in moving state might become the new hotspot and aporia in traditional Chinese pharmacokinetics studies.