| Osteosarcoma, also known as Osteogenic Sarcoma, is a malignant tumor of mesenchymal origin, is a mother cell sarcoma of bone that generates the bone tissue and trabecular bone structure, is the most common malignant bone tumors. Primary bone tumors are rare, accounting for 0.2% of all malignant tumors, osteosarcoma, primary bone tumors account for 35% of its causes is not clear at present. Osteosarcoma is divided into primary and secondary. Primary osteosarcoma is no previous occurrence of the lesion directly; secondary bone sarcoma is a lesion or previous radiation therapy were after.90% of children and adolescents is primary, and with this corresponds to over 60 osteosarcoma occurred in about 1/4 of the patients were secondary, such as Paget's disease secondary to osteosarcoma. Osteosarcoma usually 11 to 25 years old predilection to femur the most common, especially in metaphyseal and epiphyseal end of the humerus and tibia in the most common is the proximal end of the fibula above the common. Osteosarcoma tumor cell and tissue differentiation according to their direction, can be divided into type osteoblasts, cartilage-type mother cells, fibroblast cell type. Like other sarcomas, the most common metastatic sites were lung, followed by bone. The main clinical manifestations of osteosarcoma are pain, swelling, local dysfunction, symptoms of the body; osteosarcoma successful X-bone, osteolytic performance significantly subperiosteal new bone proliferation, showed a typical Codman triangle (cuff sign) "Day light of God" phenomenon, onion skin-like change and so on. In general, the higher the degree of malignancy of osteosarcoma, prone to recurrence and lung, bone metastasis,5-year survival rate, high morbidity, poor quality of life of patients.Over the past decade, advanced imaging technology, multi-drug combination chemotherapy, limb salvage surgery, lung metastases dissection and modified to carry out the classification system used, that osteosarcoma in the diagnosis, treatment and prognosis has made great progress 5-year survival has significantly improved, but osteosarcoma is still a very high mortality and morbidity of the tumor. With the Chinese anti-tumor molecular biology and cell biology, Integrative Medicine for the treatment of osteosarcoma provides a new hope.Objective To study application of traditional Chinese medicine clinical curative effect for osteosarcoma.Methods Study 36 cases of OPD(out-patient clinic) patients with surgery osteosarcoma treated mainly by traditional Chinese medicine at the sino-japanese friendship hospital of integrated traditional Chinese and western medicine internal medicine, observe1,2,3-year survival rate, recurrent lung and bone metastases, to evaluate clinical symptoms before and after treatment to Enneking functional evaluation criteria to evaluate the quality of life before and after treatment, postoperative complications, medication safety and to observe its short and long term efficacy.Results 33 patients were visited approximately 1-year survival was 96.0%, 2-year survival rate is about 94.0%,3-year survival rate is about 90.0%. Had local recurrence 4 cases, the rate was 12.1%.33 patients with Enneking functional evaluation before and after treatment, after treatment, the highest of which is divided into 30 points, lowest score 18 points, an average of 27.6 points,15 points lower than the 0 cases,15 -21 minutes in 4 cases, more than 21 points 29. Postoperative complications occurred six cases of osteosarcoma, the rate of complication was 18.2%. Medication is safe, and no obvious side effects.Conclusion Chinese medicine for treatment of primary osteosarcoma patients after surgery can improve survival, reduce the incidence of recurrence and metastasis, improve the quality of life and reduce the incidence of postoperative complications of osteosarcoma. Medication is safe, curative effect is satisfactory. |
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