Rats With Acute Vascular Endothelial Injury, The Expression Of Pecam-1 And Of Hif-la And Chinese Medicine Turmeric Its Impact

Objective: To investigate turmeric fried on acute intimal injury early in the PECAM-1 in serum and expression of HIF-la of the significance of vascular endothelial cell injury and turmeric fried regulation of endothelial cell apoptosis, PCI, find control After the "restenosis" basisMaterials and Methods: simulation technique of vascular intimal injury caused by acute intimal injury, after rats were fed fried with turmeric treatment, turmeric fried intervention group 36 and saline in the intervention group 36, with 36 sham group and 36 normal sub-group of 144 four groups served as controls. Morphology were observed 7, 14 days of simulated acute intimal injury group and turmeric fried rats intimal changes in the structure, electron microscopy apoptosis. ELISA was used to test 144 serum PECAM-1 and HIF-l levels for statistical analysis.Results:1.Turmeric fried group, saline group, sham group, PECAM-1 and HIF-la levels compared with the control group significantly different (P <0.05);2.sham group PECAM-1 and HIF-1a levels close to normal levels of the control group, was not significantly different (P> 0.05);3.Turmeric fried Group PECAM-1 and HIF-la with the saline treatment group, sham group were significantly different (P <0.05); compared with the control group was not significantly different (P> 0.05).4.Light microscopy of vascular endothelial morphological changes seen in rat arterial intimal hyperplasia after balloon injury in the early postoperative period (3-7 days) had reached its peak, turmeric fried Group inhibit intimal thickening. Electron microscopy group of fried turmeric reduced apoptosis. Conclusion:1. Turmeric fried up-regulated expression of rat HIF-1a, the PECAM-1 expression was significantly decreased, indicating that HIF-1a overexpression, PECAM-1/HIF-1a ratio increases, can inhibit the excessive apoptosis of endothelial cells. The ratio between the two is to determine whether apoptosis of important cell regulatory factors.2.PECAM-1 and HIF-la in the pathophysiology of restenosis.3.PECAM-1 serum detected with HIF-la levels of the abnormal changes that may help to assess apoptosis after vascular injury factor on vascular endothelial function and structure. 4 Light microscopy electron microscopy after simulation of vascular intimal injury early structural changes in rat endothelial cells, indicating that turmeric fried on endothelial protective effect.