Differences Of Oral Squamous Cell Carcinoma Of The Different Regions Of The Pathological Grade And Proliferation Activity

Objective: To study the difference of pathological grading (WHO 1971) and cell proliferating activity bebween different parts of oral squamous cell carcinoma, and to discuss its clinical and theretical significance. Method: Each specimens of 15 OSCC cases was devided into 5 parts , including surface ,central, deep invasive parts, tissue adjacent to carcinoma, normal. The surface , central,deep invasive part and biopsy tissue were graded respectively (WHO). To observe whether there were differences of pathological grading between these parts. PCNA immunohistochemical dyingmethod was used to study the cell proliferating activity and its differences between surface, central,deep invasive,tissueadj acent to carcinoma and normal. Results: There were pathological grading differences between differece parts of OSCC (p