| Peripheral nerve injury (PNI) is a kind of disease easy to meet, which belongs to meridian injury or flaccidity-syndrome in Traditional Chinese Medicine field. Buqi Tongluo Formula which has been made into capsule and injection is a compound Chinese herbal medicine prescription for PNI treating designed by professor He Zhenhui through long-term clinical practice. The major pathogenesis of PNI is meridian obstacle, deficiency of Qi and blood stasis, skin and muscle arthralgia due to nourishment deficiency carried by meridian. Professor He designed Buqi Tongluo Formula according to principal of therapy aiming at both the elimination of evils and restoration of healthy energy, with the methods of invigorating Qi to promote tissue regeneration and dredging collateral to promote blood circulation. Buqi Tongluo Formula composed of Radix Astragali, Radix Ginseng, Radix Angelicas Sinesis, Rhizoma Chuangxiong, Radix Saviae Miltiorrhizae etc has the function of invigorating Qi and dredging collateral. Buqi Tongluo Formula is designed for Sunderland I to 5 degree PNI after operative reparation if necessarily. Having been composed and refined in clinical study and practice through several years, the formula has each component herb's proportion was the best, and has served as a conventional prescription in No. 1 affiliated hospital of Guangzhou University of Traditional Chinese Medicine. Now the formula is made into capsule and injection so that it can be used conveniently with precise dose and absorbed completely by patients. With the aim to test the formula's effect by experiment, to discover its effective mechanism if there had any effect and to find some new medicine, method or ideas for PNI treating in the field of 1CM or 1CM-west-combined this experimental study was designed and carried out. By the light of principal of random, controlling, equilibrium forty-eight clean Wistar rat models were made after all rats?right sciatic nerves were cut and then repaired with technique of neurorrhaphy. Then all injured rats were randomly allocated to 4 groups with 12 rats in each group: group I , group 11, group III and group IV. All rats allocated to group I were treated with Buqi Tongluo Capsule, group II with Buqi Tongluo Injection, group III with vitamin B1 and B6 capsule, group IV with no drugs (blank control). Having been treated for 4, 8 and 12 weeks, each time 4 rats were randomly picked out from each group, and their Sciatic Nerve Function Index (SF1), sciatic nerve conduct velocity (NCV), tricipital muscle wet weight (TWW) and sciatic nerve axon counting (NAC) were checked and compared with each other. The results of SF1, NCV and TWW could measure functional restoration of injured sciatic nerve while the result of NAC could measure injured nerve morphological restoration. When all results of SF1, NCV, TWW and NAC were got, Buqi Tongluo Formula's effect on rats?sciatic nerve regeneration after injury could be discovered. All results revealed no remarkable difference between group I (treated with Buqi Tingluo Capsule) and group II (treated with Buqi Tongluo Injection)(P>O.05). The results of both group I and group II had remarkable difference compared with those of group III (treated vitamin B1 and B6) (p |
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