Nasopharyngeal Carcinoma Vascular Endothelial Growth Factor Expression And Microvessel Count

Objective We examined the expression of VEGF and microvessel count to investigate the correlation among them, and to evaluate its clinical significance in nasopharyngeal carcinoma. Methods EKpression of vascular endothelial growth factor (VEGF) and microvessel count (MVC) with anti-human Factor VIII-related antigen antibody marking endothelial cell were examined by immunohistochemical SR staining. Paraffin-embeded specimens from 68 cases with NRC and 12 cases with nasopharyngeal chronic inflammation as control. Results 1)VEGF was positive in 41 of 68 (60. 3%) while was negative in all thu [2 controls. 2) MVC in NRC was significantly higher than that of the nasopharynged chromic inflammation, express],on of VEGF and MVC in metastatic NPC group were significantly higher than those in non-metastatic NPC group (P<0. 01). 3) Expression of VEGF and MVC in NRC were associated with rise of clinical staging (p<0.05).4)There were significant positive correlation between the expression level of VEGF and MVC (r=0. 78559) (R<0. 001). Conclusions: Expression of VEGF and MVC are closely correlated with biological behaviors of NRC, which may serve as a parameter for predicting tumor biological behavior, metastatic potential and prognosis. Angiogenesis inhibitors might be helpful in preventing NPC from metastasis.