Tongmai Oral Treatment Of Chronic Nephritis "qi And Blood Stasis Type Of Clinical Research

Chronic glomerulonephritis (CON) is the common outcomes of various primary glomerulopathies . Before the presence of CGN, patients usually experienced a very long symptomless period with abnormal urine, then hypertension, edema and/or azotemia appears. It is a long process with continuously damaging of nephron, and ends with chronic renal failure. CON refers to "dema" onsumptive disease "umbago"etc in Traditional Chinese medicine(TCM). The mechanism is deficiency of viscera (lung, spleen and kidney) and excess of pathogenic evils (dampness, heat and blood stasis). According to many doctors?clinical practice, most patients with CON were Qi-deficiency and blood stasis, caused by Qi deficiency which leading to blood stasis and hard to recover. Compound Tong Mai Oral liquid (CTMO) was produced according to the mechanism of CGN, and composed of Huangqi, Sanqi etc. The experiments before have pronided these evidents: this formula because it eould promate blood eirculation by activating Qi. could regulat immanalogic fanction of Thy-lmodel rat, improve the hypereoagulability, deer ease the injury of the kidneys delay the glomerulosterosis, toimprove and be stablized the kidney funetion0 This reseach abjects to abserve the more elince therapeutie effect of Tongmai Koufaye0 Previous results showed that immunological function and hypercoagulable state of blood were improved in model rats, pathological damages of kidney relieved, renal function improved and kept steady, which delayed the occurrence of glomerulosclerosis. Clinical researches were carried out to study the effectiveness, toxic reactions and side effects of this formula in order to expand its applications. Single-blind, randomized controls were adopted, 60 cases recruited in treating group and 30 in control. Cases selected strictly according to the protocol. Baseline balance was acceptable within two groups in sex, age, degree of diseases and laboratory indexes. (P 0.05) CTMO was administrated 2Oml once and three times everyday in treatment and Jin Shui Bao Oral liquid (JSBO) lOml once and three times everyday in control. The 3 course was one year. Clinical symptoms, kidney function, immunological function, hemorheology and blood lipids were measured before and after treatment. Results: the effective ratio of CTMO was 95% while that of JSBO was 60%. It is significant different between two groups. (P<0.OI) Results showed that CTMO not only had the same function with JSBO in regulating immunological function (P>0.05) but also had the function of improving hemorheology, lowering blood and urine FDP, blood lipids and urine protein (P