Zgr Resistance To Acute Alcohol Poisoning And Alcoholic Liver Injury Research,

It has been found that excessive ingestion of ethanol brings about physiological dysfunctions, even to death. The Chinese medicine complex prescription ZGR was newly developed in our laboratory for the treat of acute alcoholism and alcoholic liver damage. Pharmacodynamics, mechanism, and toxicity of ZGR were also noted in this article. It was showed that ZGR counteracted to motor incoordination induced by alcoholic administration (1.6g/kg), and that ZGR suppressed the increment of pontaneous locomotor caused by alcoholic administration (2.4g/kg). it was also found that ZGR shortened mice righting-reflex loss time, decreased death rate which was caused by ethanol treatment (7.Og/kg). A lower blood ethanol level was observed in mice given ethanol (2.4g/kg) . There was no alcoholic concentration alteration after ZGR and ethanol coexisted in vitro, but the higher activity of alcohol dehydrogenase in liver was measured when mice were given both ZGR and ethanol (3.2g/kg). ZGR given for 10 days could also inhibit malandialdehyde formation and raised glutathione level in acute alcoholic liver injury. In mice with chronic liver damage induced by oral administration of ethanol (4.Og/kgld, 56 days), it was found that ZGR prevented the rise of serum glutamate pyruvate transaminase activity, restrained the decrease of the content of glutathione and malandialdehyde formation in liver. In addition, it also had effects on inhibiting the increase of liver index; enhancing the activities of superoxide dismutase in liver. It was suggested that ZGR is reliable in the treat of acute alcoholism by enhancing the activity of alcohol dehydrogenase in liver and it had a protective effect in acute and chronic liver damage that is related to aldehyde, glutathione and lipoperoxidation.