CAGA - Positive Helicobacter Pylori Infection And Gastric And Duodenal Diseases

Objective: To study the relationship between the infection of CagA~ Helicobacter Pylon (HP) and the gastroduodenal diseases by the detection of serum CagA antibody. Methods: Four hundred and twenty patients with gastroduodenal diseases (all of them Hp positive in rapid urease test and Gimes?stain) were as the subjects, including 37 cases of inactive non-atrophic gastritis, 56 cases of active non-atrophic gastritis, 60 cases of atrophic gastritis, 39 cases of gastric ulcer, 66 cases of duodenal ulcer, 60 cases of gastric cancer and 102 cases of intestinal metaplasia. Forty asymptomatic cases as control. All the subjects were received the detection of serum CagA antibody by ELISA method. Results: The percentages of CagA4Hp in patients with gastroduodenal diseases were as following: 30%(12/40) in control group, 35. 14%(12/37) in inactive non- atrophic gastritis group, 67.86%(38/56) in active non-atrophic gastritis group, 70%(42/60) in atrophic gastnitis group, 66.67%(26/39) in gastric ulcer group, 71.21%(47/66) in duodenal ulcer group, 75%(45/60) in gastric cancer group, 72.5 5%(7411 02) in intestinal metaplasia group. The total positive rate of CagA~Hp was 67.86% (285/420) in the patients and was much higher than that in control group (p0.05). There was no significance among the positive rates in different types of intestinal metaplasia (P>0.05) and in different age groups (P>0.05). 4 Conclusions: 1. The total positive rate of CagA~Hp in patients with gastroduodenal diseases was much higher than that in control group. It is suggested that CagA4Hp infection is closely related to gastroduodenal diseases. 2. The positive rates of CagA~Hp in patients with active non-atrophic gastritis, gastric ulcer and duodenal ulcer are much higher than that in inactive non-atrophic gastritis. It is suggested that CagA~Hp infection is closely related to the activity of gastritis and peptic ulcer. 3. The positive rates of CagA~Hp in patients with atrophic gastritis, intestinal metaplasia and gastric cancer are much higher than that in inactive non-atrophic gastritis, but there was no significance among the positive rates in different types of intestinal metaplasia. It is suggested that CagA~Hp infection is closely related to precancerous lesion and gastric cancer, but without relation to the types of intestinal metaplasia. 4. There was no significance among the positive rates in different age groups . It is suggested that there is no relationship between CagA~Hp infection and the patient age.