Toxic Drugs For Treatment Of Primary Liver Cancer Literature And Experimental Research

Objective: To explore the historical origins of Traditional Chinese Medicine (TCM),its?rational,clinincal applying toxic TCM drugs with others drugs,modern experimental research status and the possible anti- hepatocarcinoma mechanisms. Methods: Both of the literature and experimental research were studied. (1) The literature study included summarizing the understanding of ancient disease name of 1CM ,pathogen,pathology mechanism of Primary Hepatocarcinoma (P1-IC) by consulting ancient and modern medical data of toxic drugs, and then systematically analyzing the toxic drugs TCM rationales, and its'ancient and modern clinical utilization. (2) The experimental study included detecting As,03 with cisplatin's action on the cell growth, apoptosis, periodic return, GGT, LDH's activity and telomerase activity of two human hepatocarcinoma cell lines, QGY-7701 and QGY-7703, by GGT and LDH's activity assay,MTT assay ,Electronmicroscopy detection, Flow cytometry and telomerase activiy detection. Results: (1) From the literature study,it was discovered that PHC included ancient decease named "piqi","fuliang","jaundice"and "xietong"etc, the TCM retionales of toxic drugs anti-cancer effect were to treat the PHC with "poisonous agents"and "to resolve mass and swelling" The anti- hepatocarcinoma mechanisms of those toxic drugs involved the fragment action the induction of apoptosis and the inhibition the suppress of telomerase acitivity. (2) From experiment study,it was discovered that As203 togather with cisplatin could increase inhibiting the growth of human hepatocarcinoma cells lines,QGY-7701 and QGY-7703,decrease their activity of GGT, LDH, inducing the apoptosis of the cells and inhibiting the telomerase activity. Conlusion: It is showed that toxic drugs'anti-hepatocarcinoma effect can be greatly supported by suflicient rationals of TCM,clinical case and modern experimental research. As203 with cisplatin may increasing obviously anti- hepatocarcinoma effect, its mechanism includs the cellulotoxic, apoptosis and anti-telomerase effects.