Modified Yi Gong Scattered Experimental Study, The Anti-tumor And Attenuated Efficiency In Combination With Chemotherapy

Aim: To observe the effects and mechanisms of the Chinese Compound Prescription ?Jiaweiyigong (JWYG) powder and its combining with chemotherapeutical such as 5-Fluorouracil (5-FU) on transplanted hepatocarcinoma mice.Methods: The model of hepatocarcinoma 22 solid tumor-bearing mice was produced and treated with JWYG and JWYG combined with 5-FU respectively. The possibility of JWYG alleviating small intestinal toxicity and immune depression induced by 5-FU were studied. After giving drugs for 8 days, the inhibiting rate of tumor, the peripheral blood count, natural killer cell activity (NK), interleukin-2 activity (IL-2) and Malondialdehyde (MDA) of small intestinal were determined. The morphological change of small intestinal and the P53 protein expression of tumor tissues were also observed.Results: JWYG can remarkably inhibit the growth rate of tumor, the maximal of which was 59.22%. Compared with the group treated with 5-FU, the inhibition rates of tumor was higher, and immune functions such as the weights of immune organs, natural killer cell activity and interleukin-2 activity, and intestinal injuries induced by 5-FU were improved, the P53 protein expression of tumor tissues was lessened. It suggested that JWYG could ameliorate the prognosis of tumor-bearing and chemotherapeutical-treating animals.Conclusions: JWYG whether used solely or combined with 5-FU has good effects on inhibiting tumor growth and enhancing chemotherapy efficacy for tumor-bearing mice. These observations give the experimental proof to the clinical application of JWYG.