Yuan Hu Pain Dispersible Tablets Pharmaceutical Research

Yuanhu zhitong dispersible tablet comes from yuanhu zhitong tablet by modifying the form. Consisting of Rhizoma Corydalis and Radix Angelicae Dahuricae, Yuanhu zhitong tablet has being effective in curing many pains causing by Qi stagnation and Blood stasis, such as headache, pain in the hypochondrium and stomach, pain happening in menstruation and so on.In order to alleviate pain of patients quickly, its form is now changed into dispersible tablet which disintegrates very quickly and drug in it will dissolve faster .The study has been done on pre-clinical pharmacy including determining preparation route on the basis of pharmacological experiments associated with the function of prescription, selecting the extration and concentration technology according to the contents of tetrahydropalmatine and imperatorin .controlling the quality of extract powders dried by spraying drier ,completing the form of dispersible table which is a difficult procedure by selecting the disintegrants and diluents ,and assessing the quality of product especially establishing the metrod of determining tetrahydropalmatine by HPLC and test its dissolution and disintegrating time.As a result, Yuanhu zhitong dispersible tablet can disintegrate within 3 mimute and tetrahydropalmatine can dissolve 70% in ten minute as well as wholly dissolve after 20 minute.Besides, the quality of the product is well controlled by contyolling the qualities of the crude hurbs and semi-product.The preliminary stability and pharmacological experiments show that the product has stable and controllable quality as well as definite effect, on alleviating pain.