| Intrauterine Growth Retardation (IUGR) is a serious complication in obstetrics and an important cause of perinatal mortality. Children with a history of IUGR may possibly have a negative effect on brain growth and metal development. The IUGR condition is most commonly caused by inadequate maternal - fetal circulation, with a resultant decrease in fetal blood, oxygen and nutrition supply. Nitric oxide (NO) is responsible for the vasodilator properties of endothelium - derived relaxing factor, and NO is a adjusting factor in maintaining pregnancy. This study discusses the relations between level of pregnant rats serum NO and IUGR incidence.Material and MethodsThe weight of the usual SD female rats are 250 - 350 gram, and the rats are maiden. The weight of the usual SD male rats are 300 -400 gram, The females and the males are raised in the same cage by the proportion of five ratio one. The vaginal liquid is wiped on the flakes in the next morning, and the flakes are watched . The day when we found out sperm is looked on as the first day. The rats of the groups C,D and E are passive smoking everyday in 0.5×0.5×1m3 tobacco box. There is a blast stoma on one side of the box and there is a stoma of the letting out winds on the other side of the box. The two stomas are connected with a airtight pipe which is plastic. The three cigarettes were lighted up in 20 minutes in the tobacco box. The fanfor letting out winds and the blower is opened during lighting up the cigarettes in order that the gases are entirely blended in the tobacco box. The blower is closed after the cigarettes are completely lighted up. The rats are passive smoking for two hours in the tobacco box. The pregnant SD rats are randomly divided into five groups. Group A pregnant rats are raised in usual situation without passive smoking. Group B pregnant rats are raised in the same situation with groups CA D^E but no passive smoking. Group C pregnant rats are passive smoking two hours per day during all gestations. Groups D pregnant rats are passive smoking two hours from the 8th of pregnancy. Groups E pregnant rats are passive smoking two hours from the 15th of pregnancy. All groups are dissected in the 20th of the pregnancy . We anesthetized the rats with hydrating chlorine aldehyde. After five minutes, we dissected the rats and registered the number of the fetal rats and to take the pregnant rat serum in order to measure NO. The rats whose the number of the fetal rats are less than six or more than twelve are e-liminated. The diagnostic criterion for IUGR is that the average body weight of group A live fetal rats subtracts two standard errand. This study adopts t test and x2 test.ResultsThe increasing weights for groups A and B rats are not significantly different. The weights for group B rats increase more rapidly than other groups. The weights for group C rats increase to be significantly restrained. The increasing weights for groups D and E rats are in the middle of groups A and C . The increasing weights are significantly different between groups D and E . The average body weights oflive fetal rats in every group are partly 2. 534 ±0. 250 g,2. 538 ±0. 160 g,2. 210 ±0.164 g,2. 293 ±0.197 g,2.469 ±0. 203 g. The average body weight sof live fetal rats in group C is 2.210 gram. The average body weight of live fetal rats in group A is 2. 534 gram. There are significant difference between them. The average body weight of live fetal rats in groups A and B are partly 2. 534 gram and 2. 538 gram. There are not significant difference between them. The average body weights of live fetal rats in groups D and E are in the middle of groups A and C . The average body weights of live fetal rats in groups D and E are significantly different. The IUGR incidences in every group are partly 2. 82% ,2.47% , 18. 06% , 14. 47% ,9. 88%. The X2 of groups A and B is 0. 018. There are not significant difference between groups A and B . The x2 of groups A and C is 8. 84 . There are significant difference between groups A and C. The x2 of groups... |
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