Endometrioid Carcinoma Of Telomerase Htert Expression And Significance Discussed

Objective: To get insight of the expression of telomerase hTERT in human endometrial carcinoma and its association with the clinical property of pathology and its prognostic value in the disease.Methods: Immunohistochemistric technique was used to detect the expression of hTERT, proliferating cell nucleus antigen (PCNA), estrogen receptor (ER) and progesterone receptor (PR) in 55 cases with endometrial carcinoma, 36 cases with endometrial hyperplasia and 36 cases with postmenopausal bleeding. The results were compared with those of in normal proliferative phase endometrium and secretory phase endometrium.Results: The expression of hTERT in normal proliferative phase endometrium, secretory phase endometrium, hyperplastic endometrium, postmenopausal bleeding endometrium and endometrial carcinoma were 40%, 0%, 63.89%, 58.33% and 90.90%, respectively. The exprsssion of telomerase hTERT in patients with endometiral carcinoma was significantly upregulated, compared to those of in all other groups (P < 0.05).The expression of telomerase hTERT showed a positive correlative tendency with infiltraration of muscle and clinical stage in patients with endometrial carcinoma, but with no statistical significance (P > 0.05). The expression of telomerase hTERT in well differentiated endometrial carcinoma was lower than that of in moderate and low differentiated one but with no statistical significance (P > 0.05). The expression of PCNA in normal proliferative phase endometrium, secretory phase endometrium, hyperplastic endometrium, postmenopausal bleeding endometrium and endometrial carcinoma were 0%, 0%, 27.38%, 19.44% and 83.63%, respectively. The expression of PCNA in patients with endometrial carcinoma was remarkably higher than those of in all other groups (P < 0.05). The expression of PCNA in patients with well differentiated endometrial carcinoma was decreased compared to that of in patients with moderate and low differentiated endometrial carcinoma but with no statistical significance (P > 0.05). The expression of the telomerase hTERT and the PCNA was negatively correlated with the expression of the ER and PR.Conclusions: Hyperexpression of the telomerase hTERT may play important roles in the development and progression of the endometrial carcinoma. The combination detection of telomerase hTERT, PCNA, ER and PR is useful in judging of theproliferative and malignant status and the prognosis of the endometrial carcinoma. The detection of the telomerase hTERT can be easily achieved by immunohistochemistry, so that it might be used as a new prognostic marker for judging the prognosis of the patients with endometrial carcinoma.