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New Drug Development Of Anti-tomato Cream To Treat Eczema

Posted on:2005-04-05Degree:MasterType:Thesis
Country:ChinaCandidate:A YangFull Text:PDF
GTID:2204360122487025Subject:Pharmacy
Abstract/Summary:PDF Full Text Request
Fang Qie Ointment is a kind of pure Chinese materia medica preparation wit hout any hormone. It origins from Pyocutaneous Disease and such effective medical prescription .we made it appropriately on the basis of Chine se medical pharmacologic and experience. The medicine list on the pr escription all recorded in . Cream is also a u sually used dosage form, This paste is special and creative, mainly u sed to threat Eczema and get unique curative effect. Although there are many medicine to treat this disease internal at present, such a Fluonid Ointment Hua Tuo Ointment Pi Yan Ping Ointment , Qu Yan Song Oint ment and so on. The clinic investigation shows that the curative effe ct below the mark, easily to recur after use and cannot heal, from th is , there is still no special medicine to cure Eczema.As the successful development of our medicine, It will fill the tr eat blank internal an aboard.The attack rate of Eczema is higher than others, children is 95 percen t, the adult is about 12 percent . the raw material of this medicine is the no harm and cheap, the market outlook is broad, the expect ec onomic and social revenue is uncountable.The purpose of this project is to study the preparation procedureand quality control standards of Fang Qie Ointment. After reading and studying amounts of Chinese Medical documents, depending on the proof of clinic professors, we choose ointment as the dosage form, dealswith the preparation procedure. Quality standards and stability, formulate the paste and preparation methods of Fang Qie Ointment. We also work out the strictly quality control ways and standards during the process. Primary preview its acute toxicology and medical effects and initial probation in clinic, the concrete content state below.This project studied the preparation procedure of Fang Qie Ointmen t, tried to find the available proposal by orthogonal test. It mainl y divided into two steps. A. The preparation procedure :1. Using dry extract content and Rsveratrol , the special ingredie nt in Polygonum Cuspiclatum as index, design the alcohol-reflux preparation procedure of Stephaniae Tetrandrae , Polygonum Cus piclatunu Paeoniae Rubra Angelicae Sinensis and so on. Us in g the alcohol density, reflux time, reflux times, and the alcoh ol amount as the research factors, the optimum preparation pro cedure of was studied by orthogonal text. The reasonable and available process conditions were established.2. using the imperator in content of Angellicae Dahuricae as index,developed an optimal process of Angellicae Dahuricae, Angelic e sine sis and Lithospermi.3. Using the Capsaicin content in Capsicum anrunm as index. Design the best preparation procedure of Capsaicin.4. Using the Rutin content of Carthamus Tincterius L. as index, design the best preparation procedure of Carthamus TincteriusL. B. Make ointment :After many experiment comparative, the group qualitative beautiful match ratio The degree and the ways to research the perfect degree and effect of ointment.After research for its preparation procedure, we also work out th e strictly quality control ways and standards by TLC and HPLC during the process, the experiment proved that the stability , recovery, r eproducibility and accuracy are satisfactory . Primary preview its cute toxicology and medical effects and initial probation in clinic, The concrete content state below, valuable results were obtained, th e pharmacy study and research of Fang Qie ointment indicate, its pre paration procedure is reasonable ,quality is steady , safety and ef fective. It is a preferable compound preparation to prevent and ther apy Eczema.
Keywords/Search Tags:Fang Qie Ointment, Preparation procedure, Orthogonal test, Quality standards, Eczema Ointment, Chinese materia medica preparation Assaying, Clinical study, Primary stability, Medical effects, Acute toxic test
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