| Object:Peptic ulcer(pu) is a normal disease in internal medicine system,which has a higher incidence of attacking and recurring with the more and more acceleration of the living rhythm in the past few years, its mobidity was going up while its attacking age was going down. How to crue it has become a focus in medical research at the present time. At the same time, improving the curative effect of peptic ulcer to prevent recurrence of it is one of the problems in treating PU, Doctors of modern medicine and traditional Chinese medicine(TCM) have been searching for the effective ways to solve it. Research in resent years shows that quality of ulcer healing (QOUH) has close relationship with recurrence of Ulcer, and that deficiency of spleen and stomach, staynation of Qi and blood,and alternate attacks of chills and fever are the main pathologic mechanism to affect QOUH. So, according to clinical practice that Jiaweibanxiaxiexin decoct ion(JBD) can treat PU and prevent relapse of PU, investigate the possible mechanisms of resisting recurrence of Pu and protecting gastric mucosa, provide the theory reference data for clinical practice, and do many things for quiding the clinical practice and finding a new traditional Chinese medicine on mucosal pretection.Methods:ninety Wistar big white rats were randomly divided into 6 groups: normal control group, Model group, 20g/kg JBD group, 10g/kg JBD group; 5g/kg JBD group and cimetidine group. Except normal control group, rats were induced chronic gastric ulcer with 100% aceticacid. At the sixth day after being modeled, all of the rats were treated for sixteen days (The rats of the normal control group and model group were fed on equal physiological saline). Sixteen days later, all the rats were picked their eyes away to collect blood in order to detect PGE. ET, Kill the rats and get stomach tissue for SOD, MDA, NO, EGF, determine the thickness of regenerative mucosa, the thickness of mucus gel layer adherent mucosa in Ulcer scar and the thickness variations of granulation tissue which were made by micro scopic ruler.Result:The determination of the thickness of mucus gel layer adherent mucosa on chronic gastric ulcer rats has showed that 20g/kg JBD group, lOg/kg JBD group, 5g/kg JBD group and cimetidine group all can increase the thickness of stomach mucus gel layer adherent mucosa in raring degrees, whose curative effective is better than model group (P< 0. 05 ~ 0. 01) . There was not very remarkable difference between the 20g/kg JBD group and the normal group (P > 0. 05), and there was significentdifference between the 20g/kg JBD group and the cimetidine group.The determination the thickness of the regeneratice mucosa on chronic gastric ulcer rats has showed compared with normal control group, the thickness of gastric mucosa decreased significantly in the model group((P <0.01 ) , Compared with model group, the thickness of regenerative mucosa increased and cystic dilative glands decreased in the 20g/kg JBD, 10g/kg JBD ,5g/kg JBD and cimetidine group (P<0.05~ 0. 01 ) .There was remarkable difference between the 20g/kg JBD group and the cimetidine group(P< 0. 05 ) . and there was not significant difference between the 20g/kg JBD group and the normal control group (P> 0.05).The determination of the thickness variations of granulation tissue in the ulcer region on chronic gastric ulcer rats has showed that (20g/kg, lOg/kg , 5g/kg)JBD group of the granulation tissue in the ulcer region in different degree; There was not remarkable difference between the 20g/kg JBD group and the normal control group (P> 0. 05), Compared with cimetidine group, the thickness of granulation tissue in the ulcer region didn't increase significantly in the 20g/kg JBD group(P > 0. 05), There was remarkable difference between the 20g/kg, 10g/kg , 5g/kg JBD and cimetidine group and model group (P< 0.05~ 0.01).The determination of the content of PGI2 has showed that there was very remarkable difference between model group and normal control group(P< 0. 01 ) . There was higher... |
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