| Objective:To observe the clinical effect of Wenjinghuayuzhitong Formula (WJ for short ) on treating Primary Dysmenorrhea ,and provide scientific basis for the clinical application of it .Methods:60 cases of Primary Dysmenorrhea were divided into two groups randomly as Traditional Chinese Medicine treatment group and western-medicine control group , each of them contained 30 cases and was given WJ and metacen respectively for orally taking .Both groups started at 4 days during the menstrual period and lasted 7 days ,a course contained three menstrual cycles , we valuated the clinical effect of each group after a course and chose acesodyne effect , scores of the clinical symptoms before and after the treatment as the observing indexes .Results:1 The recovery rate of WJ is 40.00% ,the total effective rate is 93.33% ; which of metacen is 10.00% and 63.33% respectively .By means of statistics analysis .there is statistical difference between these two groups on the clinical effect (P<0.05 ).It states that the clinical effect of the treatment group is better than that of the control group .2 On the acesodyne effect ,the effective rate of WJ is 86.67% , the effective rate of metacen is 53.33%.There is statistical difference between these two groups (P<0.05) . It shows that the acesodyne effect of WJ is better than that of metacen .3 Both groups can ameliorate correlate clinical symptoms in certain level ,especially the treatment group (P<0.01) .Comparing each group on the same symptoms after treating, the treatment group has significant difference from the control group on the amelioration of cold sensation in the body and aversion to cold ,scanty menorrhea with purplish color menses and clot,etc. (P<0.05) ,there is no significant difference between the two groups on the amelioration of the other symptoms (P>0.05) .4 The investigation of the relative factors and the clinical effect shows that the effect is relevant to age ,patient's state ,stage and course of the illness .The clinical effect of the younger ,slighter state,lower stage and longer course is probably better than the others . Conclusion:WJ can treat Primary Dysmenorrhea and ameliorate the correlate symptoms through its good acesodyne effect and regulating the body as a whole . The mechanism is relevant to the function of WJ on significantly increasing the blood - flux ,expanding the vessels,accelerating the dissipation of the gores ,distoling the uterine smooth tissue and regulating the internal secretion . These can ameliorate the nutrition state and the scanty-oxygen state of the uterine smooth tissue ultimately . |