The Fufangjiakang Capsule Pharmaceutical Research

Jiakang compound capsule , which is made from Radix Astragali , Radix Paeoniae Alba , other seven kinds of herbs and Thiamazoli , is an effective prescription of combination of traditional Chinese and Western medicine , for treating hyperparathyroidism by reinforcing Qi, nourishing Yin , smoothing liver , regulating Qi , dispelling nodule and eliminating wart . The author has made an experimental study on its preparation, quality standards and primary pharmacodynamics .1.Study of the preparationIn the point of preparation technology, we used the content of Paeoniflorin and extracting ratio as evaluating indexes and investigated the optimum preparing and refining conditions by the orthogonal test method and parallel test . The optimum extracting condition was : soaking the nine herbs with water for 3 hours and boiling 1.5 hours for two times , the amount of water used was 9.5 , 8 times of the drug mixture respectively . Then concentrating the extracting liquid and adding the ZTCl+1 natural clarifier in the concentration in order to purify it . On the basis of these studies , we selected the mixture of carboxymethyl starch sodium(CMS-Na) and microcrystalline cellulose(MCC) as the excipients to reduce the hygroscopy and increase the fluidity of extracting powder .2. Study of quality standardThe Radix Astragali , Radix Scrophulariae , Ramulus Uncariae Cum Uncis , Fructus Schisandrae Chinensis and Radix Curcumae were indentified by TLC . For the sake of assays of Paeoniflorin and Thiamazoli ,the new high performance liquid chromatography methods were developed . The average recovery rates were 95.74% and 99.02% respectively while RSD were 1.04% and 1.86% respectively . Assay methods were validated in the research of contert . On the basis of the above-mentioned quantitative analysis menthods for Paeoniflorin and Thiamazoli, the quality standard of Jiakang compound capsule was drafted .3. Study of primary pharmacodynamicsOn the basis of steady preparation technology , we engaged in experimental study to prove the preparation's curative effect . We set up three groups which have different dosages of Jiakang compound capsule ,and compared their effect with Traditional Chinese medicinal group and western medicinal group . The results show that Jiakang compound capsule can relieve hyperthyroidism symptom ,increase avoirdupois , and decrease the content of TT3, TT4 . The functions of it are more powerful than those of Traditional Chinese medicine and western medicine .