Fufangjiakang Film Pharmaceutical Research

Jiakang compound tablet, which is made from Radix Astragali, Radix Paeoniae Alba , other seven kinds of herbs and Thiamazoli , is an effective prescription of combination of traditional Chinese and Western medicine , for treating hyperparathyroidism by reinforcing Qi, nourishing Yin , smoothing liver , regulating Qi , dispelling nodule and eliminating wart . The author has made an experimental study on its preparation, quality standards and primary pharmacodynamics . 1. Study of the preparationIn the point of preparation technology , we used the content of Paeoniflorin , astragaloside IV and extracting ratio as evaluating indexes and investigated the optimum preparing and refining conditions by the orthogonal test method and parallel test. The optimum extracting condition was : soaking the nine herbs with water for 3 hours and boiling 1.5 hours for two times , the amount of water used was 9.5 , 8 times of the drug mixture respectively .Then concentrating the extracting liquid and adding the ZTC1+1 natural clarifier in the concentration in order to purify it. On the basis of these studies , we selected the mixture of silicon Gel(SiO2) and microcrystalline cellulose(MCC) as the excipients to reduce the hygroscopy and increase the fluidity of extracting powder . The optimizing spray pelletization technology was confirmed, the frequency of main fan was 35.0 ± 5Hz,atomizational pressure was 0.1Mpa,the rate of spray was 1.2Hz,the density of liquid medicine was 1.20g/ml.In prove of the rationality and feasibility of the techniques, the techniques was enlarged 10 times for 3 group.2. Study of quality standardThe Radix Scrophulariae , Ramulus Uncariae Cum Uncis , Fructus Schisandrae Chinensis and Radix Curcumae were indentified by TLC . and it was verified that , Provide to try an article color to compose to win, in checking against the position that the medicine material color table corresponds, the spot of all same color, and the feminine gender check against be corresponding position to then have no interference。 For the sake of assays of Paeoniflorin, astragaloside IV and Thiamazoli ,the new high performance liquid chromatography methods were developed ., RSD分别为 1.05%, 1.84%, 1.15%The average recovery rates were 96.04%, 98.39%, 96.45%, respectively while RSD were 1.05%,1.84%, 1.15%. Assay methods were validated in the research of content . On the basis of the above-mentioned quantitative analysis methods for Paeoniflorin , astragaloside IV and Thiamazoli , the quality standard of Jiakang compound tablet was drafted.The content of astragaloside IV is all of 0. 1145mg, the content of Paeoniflorin is...