| Compound Kanggan granules is a new compound preparation of Traditional Chinese Medicine, which consists of Herba Bupleuri, Herba Schizonepetae, Rhizoma Atractylodis Macrocephalae,Herba Moslae and Herba Pterocephali.It has the function of dispelling wind-evil, dispersing pathogenic factors, eliminating dampness, harmonizing stomach and spleen, clearing away heat and alleviating pain.Therefore It can be used to cure such symptom as fever, aversion to cold, headache and bodily pain, throat swelling and pain because of the upper respiratory tract infection.With the guidance of the theories of Traditional Chinese Medicine, Compound Kanggan granules was studied on pre-clinical pharmacy with modern pharmaceutical technology. For the demand of clinic, the form of drug was chosen as granules. On the basis of the function and treatment as well as the characters of the component of the herbs, the optimum extract conditions about alcohol-extract and water- extract were selected by using orthogonal design which use quite a few assessing norms to evaluate them comprehensively. Meanwhile,the extract of volatile oil and the combination of B -cyclodextin with it have been completed. After that the quality standard of the Compound Kanggan granules was finished. Determine the content of Herba Bupleuri in Compound Kanggan granules by RP-HPLC. Use TLC to identify Herba Bupleuri, Herba Schizonepetae and Rhizoma Atractylodis Macrocephalae. Then the preliminary stability was fulfilled. That research indicates that the technique of preparation was reasonable and practical, the standard was controllable and the quality of the sample were steady as well. |