Houttuynia Injection Preliminary Experimental Study Of Membranous Nephropathy In Rats

OBJECTIVE:The study was designed to observe the effect of herba houttuyniae on SD MN rats and discuss it' s mechanism of action.METHODS: SD rats were made to membranous nephritis model by cation bovine serum albumin and divided into 4 groups, the model group, the high-dose and low-dose houttuynia group, Dex group. Heathy rats were usedas normal contral group. Twenty-four hours' urinary protein content and plasma albumin, blood lipid were tested by the end of experiment. Pathological changes were observed by using light and used immunohistochemistry staining test.RESULTS: As compared to model group, high-dose and low-dose houttuynia group rats showed less urinary protein excretion(P<0.05), Light , immunohistochemistry staining all showed that the pathologic changes in the high-dose and low-dose houttuynia group were lesserthan that of the model group. Especially the high-dose houttuynia group.CONCLUSION: Houttuyniae can reduce urinary protein content. Houttuyniae also can reduce the pathologic changes of SD rats were made to membranous nephritis model by cation bovine serum albumin.