Intraoperative And Postoperative High-dose Methylprednisolone In Preventing The Effect Of Severe Spinal Cord Compression, Laminectomy Reperfusion Injury Observed

Reperfusion injury,protrusion of the lumbar intervertebral disc,tumour of spinal,etc,compress the cervical cord slowly,that comes the adaptability,but sometime the compression may severe,it often need the operation to decompress.Frequently after the decompression procedure it cases the pinal ischernic reperfusion injury(SIRI),that cases functional diordered,or the unreversible injure of the spinal,that impress the impression of the operation. Methylprednisolone (MP) has been comprehesive studied on the spinal cord injury (SCI),but there is few studies on the pinal ischernic reperfusion injury of the decompression.The study is to observe the clinical effect of the pinal ischernic reperfusion injury afer the decompression procedure of the severe compression.Objective:To compare the curative effect between the Methylprednisolone and the nomal treatment on the decompression procedure of the severe compression.Methods:the 29 patients of the severe compression of the spinal of DongZhiMen hospital from June 2004 to March 2006. They were randomly divided into two groups: observation group of 19 cases and control group of 10 cases.19 cases of those randomly selected were treated with sufficient dose MP before and after decompression procedure.MP was administered according to 30mg/kg within 15 min that 30 min before the decompression,and 5.4mg/kg in the leaving 23 hours.1day after the operation it become 80mg twice a day,and it cut off after a week. Before the operation and 1day ,7day,1month,3month after the operation we do the functional evaluation of JOA. Results:The functional evaluation of the 1day and 7day after the operation in observation group has a total effective result (P<0.01),and there is almost no difference on the evaluation of 3month after the operation(P>0.05).Conclusion:Adminstering sufficient megadose of methylprednisolone before and after decompression procedure can effectively prevent secondary the spinal ischernic reperfusion injury and significantly improve spinal cord function.And complications such as digestive ulcer,infection,cardiovascular system failure related to MP are...