Lpd Solution Containing Ambroxol Hydrochloride In The Lung Protective Effect Of Cardiopulmonary Bypass

OBJECTIVE To evaluate the protective effect of pulmonary perfusion with LPD solution contained ambroxol on lung function during cardiopulmonary bypass (CPB) and its mechanism.METHODS: Twenty patients with mitral valve replacement in this prospective study were divided randomly into the protective group (n = 10, LPD solution contaied Ambroxol) and the control group (n = 10, LPD solution). The same anesthesia method, equipment and management of ardiopulmonary bypass were used, the procedure of mitral valve replacement was similar between the groups. 10-12° C solutions were perfuse (20ml/kg/min) by the main pulmonary artery during the ascending aorta clamped. A series of arterial blood samples were analyzed at five different time points: 0 hours, 1 hours, 2 hours, 3 hours, 6 hours, 12 hours, in the intensive care unit (ICU). Pulmonary function indexes were calculated. Blood samples were collected for measuring concentrations of malondialdehyde(MDA) and superoxide dismutase(SOD) at four different time points: preoperation, 0 hours, 12 hours, 24 hours, in the ICU. All patiens blood cell counts was obtained as well. Time of CPB, aortic cross-clamp time, mechanical ventilation time and ICU monitoring time, in-hospital time after operation were recorded. Data were analyzed by...