The Sinomenine Cataplasm Developed

Sinomenine is an alkaloid isolated from the stem and root of Sinomenium acutum (Thumb) Rehd et Wils, and the leaves of Menispermun dauricum DC. At present sinomenine is mainly used in the treatment of Rheumatoid Arthritis (RA). Its salt, Sinomenine Hydrochloric (SM) is more popular in clinical use. However, oral administration of SM sometimes leads to the side effect of gastrointestinal complaints (e.g. nausea, diarrhea, constipation, gastralgia and occasionally vomiting). Thus, the Transdermal Drug Delivery System is expected. And specifically in this thesis, it's Cataplasm.Firstly, the methods of UV Spectrum Photometry and High Performance Liquid Chromatography (HPLC) were established, and some physicochemical properties were determined. Such as equilibrium solubility, Oil/Water and Epiderm/Solution partition coefficient, the stability in solution, and the effect of pH value on them etc.On the basis of preformulation, the transdermal delivery of SM across excised rat skin was studied with modified Valia-Chien diffusion cell. The influence of receive media and its pH value, SM concentration, and different period of cold storage on the percutaneous permeation of SM was investigated. The results indicate that pH 8.03 PBS solution, 10mg/ml SM, and skin stored no longer than 1 week after excised from live rats is preferable for the permeation test. Furthermore, the permeation enhancement effect of several Permeation Enhancers (PE) and Complex...