Chinese Medicine The Dgh Capsules On The Spontaneous Diabetic Rats Vitreous Vascular Endothelial Growth Factor And Retinal Morphological Damage In Rats

Objective:to study the effects of DGH on the growth facter in vitreous and retinal microvascular impairment of the experimentally GK rat,a Spontaneous Model of Non-Insulin-Dependent Diabetes, and to explore the pathology mechanism of how the Chinese Medicine treating DR.Methods:After observed 6 months ,GK rats were randomly divided into 6 groups according to the weight and the level of blood glucose: model group ,treated groups with high,middle and low dosage of DGH ,positive control group of Difral and Doxium ,also there are normal group. After given drugs or distilled water for 3 months, the rats were put to death , eyeballs of the rats were taken out. Their vitreous and retinas were studied by means of ELISA and immunohistochemistry respectively.Results:(1) DGH has the effect of improving the existing behavior of GK rats. (2) DGH can reduce the level of insulin-like growth factor-1 of GK rats in vitreous. (3) DGH can inhibit the proliferation of type IV collagen of retinal capillory basement membrane of GKrats. (4)DGH can decrease the blood glucose of GK rats in some degree.Conclusion: DGH capsule can inhibit the proliferation of type IV collagen of retinal capillory basement membrane of GK rats and decrease the level of insulin-like growth factor-1 of GK rats in vitreous , so it is a good capillary protective agent to the GK rats'retinal impairment.