Neural Cell Adhesion Molecule (ncam), Nerve Growth Factor Receptor (ngfr/p75nrt) Expression In Salivary Adenoid Cystic Carcinoma And Its Clinical Significance

Objective To investigate the expressions of neural cell adhesion (NCAM) and nerve growth factor receptor p75NTR(NGFR) in salivary adenoid cystic carcinoma (SACC) and discuss its clinical significance.Method The expressions of NCAM and NGFR were detected by immunohistochemical technique in 49 cases of human salivary adenoid cystic carcinoma tissues.Results In 49 cases of human SACC, the positive rate of NCAM and NGFR were 57. 15% and 65. 13% respectively. There was no significant difference in the expressions of NGFR between SACC of different pathological types. There was significant difference in the expressions of NCAM between SACC of 20 cases tubular subtype and 12 cases solid subtype. NCAM and NGFR expressions in 33 cases with neural invasion were significantly higher than that in 16 cases without neural invasion (P<0. 05).Conclusions In human SACC, the expression of NCAM and NGFR were closely correlated with neural invasion of SACC. NCAM and NGFR play cooperatively important roles in the character of neural invasion of SACC.