Canopy Bulk Dispensing Granule Decoction With Traditional Decoction Of The Active Ingredient And Antibacterial Experimental Study

Object:The prescription of Huagaisan ,was recorded in《Peace and Tranquility Hui Min County Formulary of Peaceful Benevolent Dispensary》, This prescription is being listed in clinically quilt being used for relieving cough and asthma broadly , cures chronic diseases such as bronchus,asthma, and has the fairly good effect。Difference comparing compound decoction and concentrated granule decoction with four pellet herb broth room leading indicator components contents, the herb broth bacteriostat rates , the pesticide effect being to go a step further learn to study comparatively two kinds laying down basis。Methods:To make use of clinical tradition herb broth decocting methods to get the traditional decoctions, adopt big commercial runs taste to concentrated granule method , the preparation concentrated granule herb broth;and adopt HPLC to determine the ephedrine hydrochloride, amygdalin , glycyrrhizic acid, glycyrrhiza glycoside in this two kinds herb broths。Result:1. To collect the method arranging and inspecting , summing up out a set of the preparation being able to represent the method that popular herb broth routine decocts as scattered tradition of problem China cover herb broth by the data to that the decocting apparatus , grind , decocting time , decocting temperature , the quantity of the added water , soaking time and so on that the herb broth decocts。Concrete method is:according to the proportioning of the prescription, fetch ever medicinal material as Ephedra sinica,Semen Armeniacae Amarum,Cortex Mori,Pericarpium Citrus Reticulata,Fructus Perillae,Poria Cocos every 9g,Glycyrrhiza 6g,cold soak 20 mins,decocts two times with water,one fries a highball poison 4 cms of surface extremely,tiny boiling 30 mins;two fries also add water poison 4 cms of surface extremely , tiny boiling 20 mins, amalgamate the filter liquor,concentrating,dessicate in the normal pressure and low temperature(80℃),then get the tradition herb broth extract powder。2.The contents of ephedrine hydrochloride, amygdalin , glycyrrhizic acid and glycyrrhiza glycoside were difference in traditional decoctions and granule decoctions。Result is demonstrated : the content of ephedrine hydrochloride in traditional decoctions is 6.5011mg/a dose,in granule decoctions is 7.0901mg/ a dose;the content of amygdalin is5.8082mg/ a dose,6.2471mg/ a dose in each decoction;the content of glycyrrhizic acid is 2.4929mg/ a dose,7.5991mg/ a dose;the content of glycyrrhiza glycoside is 1.1844mg/ a dose,1.8869mg/ a dose。The contents of the foue component in traditional decoctions are more than granule decoctions。3. To do the diffrente compatibility of materials according to the alkalinity and acid of the component to analyze the prescription,and analyze the affect of decocting time to the change of the foue components。Result is demonstrated:the change of the foue components has no connection with the decocting time,but it have relation to the interaction of the medicinal materials。4.By the inspection of the bacteriostasis experiments , result is demonstrated : the bacteriostatic action of granule decoctions is better than that of the traditional decoctions。...