Based On The Tripterygium Toxicity Compatibility Group Side Nephrotic Female Rats Reproductive System Effects Of Experimental Research

Objective: Tripterygium wilfordii that the curative effect is distinguished and bigger toxicity traditional Chinese medicine gives first place to medicine, the medicines compatible adjusting and protecting the poisonous target function forms method, through break the side comparatively,we can analysis to the prescription combination that is the small toxicity and the good curative effect; Make building the train of thought and method by the fact that taking medicines compatible realizes the attenuation.Methods: Literature research methods of Chinese medicine, experimental method, dismembering and evaluating methods, toxic effect estimating methods combine attenuation synergy, As a guide, traditional Chinese medicine decreasing toxicity, according to the the concrete conditions adopt medicines method such as mutual suppression, adjuvant, coordinating the drug actions of a prescription, integrating pathology and toxicology research, Triptolide that the powerful role of toxic drug with several medicine (Complex Prescription Tripterygium Wilfordii Decoction), Comparing with a few groups, study the attenuate that the results that intervene model of nephrotic syndrome animal in the implementation. As ADR injection in tail vein of rat cope Minimal Change Nephropathy, inspect Progesterone, Foilicle stimulating hormone and Luteinizing hormone, and pathology of ovary and womb the protection for female rat reproductive system.Results : Through compare Public the normal group and the normal group, t-test p＜0.01, has statistical significance, Triptolide confirmation of the female reproductive system are varying degrees of damage; Serum hormone levels for evaluation, after One week ,administration of serum hormones (Progesterone, Foilicle stimulating hormone and Luteinizing hormone) leigan group, leigui group, the whole recipe by t-test p＜0.05, after two weeks, leigan group, leigui group and the whole recipe by t-test p＜0.01 with a significant difference. The results show that the whole recipe, leigan group, leigui group has increased progesterone level, lower follicular mature promoting hormones and luteinizing-role; Light microscopy showed that the whole recipe, leigan group, leigui group pathology of ovary and womb the pathological damage has diminished.Conclusion: (1) Triptolide soup compound reduces damage of female mouse with nephropathy reproductive system and improves role of P,FSH and LH, leigan group, leigui group of the reproductive system with the group similar to the regulatory role. The above nephropathy female reproductive system conside the impact of triptolide compatibility with the corresponding drugs. (2) Comprehensive use of Chinese medicine theory that is mutual suppression, adjuvant,coordinating the drug actions of a prescription and with a target of toxicity, The prescription that the toxic effect of outstanding larger medicine combinations can reduce the toxicity; (3) Compatibility confirmed through a target is to reduce the toxicity, should be combined with other targeting damage to the compound triptolide attenuated role soup made an overall judgment.; (4) Through medicine can be realized by the toxic drug slowed the purpose of its toxicity, because of many factors ,we need in-depth study in order to establish a complete, scientific and operat the way and thinking.