Chinese Medicine Syndromes Of Acute Pancreatitis And Cytokines And Related Substances Based Research

Acute pancreatitis (AP) is one of common diseases, the majority of patients were self-limited, about 20% of patients with onset of severe acute and dangerous disease, its essence is a systemic inflammatory response syndrome (SIRS), Local complications can occur, multiple organ dysfunction syndrome (MODS) or even death. Early identification of severe acute pancreatitis (SAP), to take timely interventions, can reduce complications and reduce mortality. At present the AP traditional Chinese medicine research more focus on treatment, its focus on dialectical therapy, stressed the overall coherent, but TCM type more active, no objective basis, induce TCM type to be hard to normalize, So medical circles constantiy pay close attention to the investigation of fidelity and normalization and quantization about TCM type. Recently,some scholars introduce test facility of Westerm medicine to TCM ,trying to explore objective basis from these physics and chemical quantization index. Through the following two aspects of TCM and the AP of the correlation between, with a view to the next large-scale clinical trial of seeking TCM objective basis to provide guidance, and ultimately achieving the TCM normalization: 1, to observe patients admitted to hospital with serum TNF-a, IL-6, ICAM-1 and P-Selection of the level, understanding of the correlation of these indicators levels and the TCM-related. 2; to observe patients admitted to hospital with the related substances basis of the level, understanding of the correlation of these indicators levels and TCM-related.Objective: To study the levels of cytokines, the related substances basis ,and explore its TCM-the correlation between.Methods: AP patients admitted to hospital within 24 hours of traditional Chinese medicine look, it is asked, all four examinations, under the existing sub-standard TCM, into the case of a Syndrome, that the law permits distribution; testing patients admitted to hospital 24 hours serum TNF-a, IL-6, ICAM-1 and P-Selection and conventional blood and blood biochemical markers, understanding of the leveles and changes of these indicators and TCM- the correlation between.Major findings:The first part Disease of Trational Chinese Medicine and serum TNF-a, IL-6, ICAM-1 and P-Selection of the relationship1. serum IL-6, TNF-α, ICAM-1 and P-Selection level early in the AP that is significantly higher, compared with the control group significantly, the analysis of variance, the differences were significant (P <0.01) .2. serum IL-6 in the AP spleen and stomach is the highest expression of cards, followed by the liver and gallbladder hot and humid card, certificate Liver Depression Sizhi, the analysis of variance, the differences were significant (P <0.01).3. serum TNF-αin the AP spleen and stomach is the highest expression of cards, followed by the liver and gallbladder hot and humid card, certificate Liver Depression Sizhi, the analysis of variance, the differences were significant (P <0.01).4. AP Liver Depression Sizhi permit serum level of the lowest ICAM-1, significantly lower than the liver and gallbladder and spleen and stomach is hot and humid heat syndrome (P <0.01), and liver and gallbladder and spleen and stomach card is hot and humid heat syndrome between serum ICAM-1 levels of non-discrimination (P> 0.05).5. AP Liver Depression Sizhi permit serum P-Selection minimum level, significantly lower than the liver and gallbladder and spleen and stomach is hot and humid heat syndrome (P <0.01), and liver and gallbladder and spleen and stomach card is hot and humid heat syndrome between serum no difference in the level of P-Selection (P> 0.05). the second part Diseases of Traditional Chinese medicine and related material basis of the relationship1. AP than a three-card Congdadaoxiao were arranged for Liver Depression Sizhi (43.5%), liver and gallbladder hot and humid (38.8%), spleen and stomach Heat (17.6%), Liver Depression Sizhi tips for the most prominent early AP The pathological performance.2. SAP for the largest proportion of the spleen and stomach is hot, to 73.3 percent, followed by liver and gallbladder hot and humid, Liver Depression Sizhi, suggesting that AP is the spleen and stomach Heat in patients with the most severe, more serious illness.3. AP risk factors, with biliary of the largest, accounting for 45.9 percent of all cases, but from a single card in the cause of the composition, in hot and humid card in the liver and gallbladder to the highest proportion of gallstone, or 75.8 percent, while alcohol and food festival in Liver Depression Sizhi not in the cards for absolute superiority in the test, had a significant difference (P <0.05).4. serum total bilirubin and direct bilirubin in the liver and gallbladder AP card in the hot and humid Liver depression levels were significantly higher than the spleen and stomach Sizhi card and it is hot permits, the test had a significant difference (P <0.01).5. blood calcium levels in the liver and gallbladder AP hot and humid card, Liver Depression Sizhi card and the spleen and stomach is in the level of permits were dropped, the spleen and stomach Heat permit the lowest level of calcium, the test had a significant difference (P <0.01).6. glucose levels in the liver and gallbladder AP hot and humid card, Liver Depression Sizhi card and the spleen and stomach heat is gradually increased the level of certification, certification of the spleen and stomach is the highest blood sugar levels, the test had a significant difference (P <0.01). Conclusion:1. AP TCM distribution and changes in a specific law. AP Liver Depression to the early onset Sizhi card-based, with the condition of progress to severe liver and gallbladder in hot and humid heat card or certificate is the spleen and stomach. A certificate from the type of Liver Depression Sizhi card account for the largest proportion, and the spleen and stomach is in severe heat syndrome in patients with the greatest proportion.2. serum IL-6, TNF-α, ICAM-1 and P-Selection level in the AP that there were significantly higher to control group, it that the IL-6, TNF-α, ICAM-1 and P-Selection with the AP development has a certain relevance.3. AP spleen and stomach Heat permit serum IL-6, TNF-αlevels than the other two cards-increased significantly, and with the certification of evolution and change,and synchronize clinical pationents condition level.So considering IL-6, TNF-αlevels to reflect patient degree of injury, Therefore serum IL-6, TNF-αlevels can be used as a hot and humid AP hepatobiliary an index card.4. AP Liver Depression Sizhi card serum ICAM-1 and P-Selection low level of expression, significantly lower to other two cards-increased ,Explain that different TCM types exist different patho-material basis,can be used as an AP Liver Depression Sizhi card index card.5. AP hepatobiliary hot and humid permit the highest level of serum bilirubin, spleen and stomach is followed by heat syndrome, Liver Depression Sizhi card minimum. Therefore serum bilirubin levels can be used as an AP spleen and stomach Heat index card.6. AP spleen and stomach Heat permit blood calcium levels than the other two Syndrome decreased significantly, and with the certification of evolution and change. In a certain extent, is an inferred from the body of qi and blood Jinye one of the objective material basis and can be used as a heat AP spleen and stomach is an index card. 7. AP spleen and stomach Heat permit glucose levels than the other two cards-increased significantly, and with the certification of evolution and change. Inferred from certain extent, glucose levels in TCM is the objective of changing the basis of the material, but also can be used as a heat AP spleen and stomach is an index card.