Clinical And Experimental Studies Boxintong Capsule Prevention And Treatment Of Angina Pectoris

Objective:Observation of heart capsule risk of coronary heart disease (Cronary heart disease CHD) clinical efficacy in patients with angina, ECG changes, lipids, platelet aggregation, as well as the impact of experimental research on the risk of heart capsule after balloon injury vessel wall MMP 2, PCNA and I - collagen positive cells and their impact on the area of vessel wall. Its treatment of angina pectoris clear effect on heart risk Capsule treatment of angina pectoris physiological mechanism for the clinical use of cardiac risk of angina pectoris capsule to provide a scientific basis.Method:Clinical study: 60 patients with coronary heart disease patients with angina were randomly divided into two groups to risk heart capsule, the control group given Suxiao Jiuxin pill, both groups for four weeks, after the end of treatment compared two groups of clinical efficacy, before and after treatment Electrocardiogram, blood lipids and platelet aggregation test results.Experimental Study: pre-selection of healthy male SD 64, were randomly divided into sham group, model, the control group of Chinese medicine and western medicine control group two groups, each of the eight, the use of carotid endarterectomy balloon injury model, making Die gavage administration immediately after the success of, respectively, after the operation 2 W, 4W rats were killed, isolated carotid artery, removal of the target vessel, the conventional pathological slices, light microscopy intimal hyperplasia situation. And open the chest rats, rats sterile syringes from the left ventricle direct blood, serum and a centrifuge vessel wall of MMP, PCNA and collagen I positive cells expression.Results:Clinical research: clinical efficacy in the treatment group and the improvement of the electrocardiogram and near to the control group, in adjusting and improving blood lipid platelet aggregation rate better than the control group.Experimental Study: vascular morphological changes: sham group of carotid endarterectomy only see single endothelial cells, immediately after balloon injury that artery endothelial denudation, vascular injury after 14 d of vascular intracavity that the proliferation of VSMC, neointimal Formation of neointimal thickness and size of injury after 28 d of the most, the injury time point in the film thickness without significant changes, after injury 14 d largest cross-sectional area, the area of endometrial hyperplasia caused lumen stenosis; injury after 28 d expansion of an artery Retraction. Various time points treatment group compared with the model group differences in a very significant difference (P <0.01), February 2 drugs showed no significant difference, of which the Chinese Xiaocong group thickness than Lipitor group, but strong in the valsartan group . Vascular wall matrix metalloproteinase-2, PCNA and I - collagen positive cells expressed P<0.01 vs the same time the model group.Conclusion: Capsule heart risk could significantly reduce low-density lipoprotein and platelet aggregation, increase high-density lipoprotein, improve the symptoms of patients with angina pectoris, a middle inhibit proliferation of smooth muscle cells.