Gout Particle Treatment Of Acute Gouty Arthritis Clinical Studies

ObjectiveGout,purine metabolism disorder is caused by increased uric acid production and / or reduce the excretion of uric acid caused by a group of diseases.Patients with acute gouty arthritis is a common cause of treatment,more than 90%of patients due to decreased excretion of uric acid,uric acid production is a few too many. Crystallization of blood uric acid can be deposited in the joints,and soft tissues of the kidney to produce clinical symptoms:gouty arthritis,gout and gouty kidney stone. With the improvement of living standards,changes in the structure of diet,the incidence of gout has increased year by year,the younger emerging trends and the current modern medicine has no effect on the ideal of preventive measures,all of western medicine have different degrees the adverse side effects and reflect.At the same time,recurrent gout has the characteristics of the patients and more difficult to receive long-term treatment of Western medicine.Clinical against gout at the same time gradually increased incidence of recurrent have the characteristics of many scholars Differential Treatment methods used in Chinese medicine for its treatment of the more recognized.Therefore,how to discover safe and effective diagnosis and treatment of the traditional measures,is a very significant issue.Tongfeng particles from the original "Shanghan Lun" by the "Baihu Tang" (gypsum,Anemarrhena,licorice,japonica),it has been the subject for Modified from clinical experience,combined with modem herbal pharmacology conclusion of the study,identified by Shengdangao,Anemarrhena,TPG,BINE OF LONICERA JAPONICA THUNB,coixenolide,Scorpio and the front grass and soil Fuling, licorice fixed composition of the particles gout,a Qingre,Lishi,Tongluo,analgesic efficacy.Early pharmacodynamics of experimental results show that:Tongfeng particles can significantly reduce rat model of hyperuricemia hematuria acid;uric acid sodium salt crystallization of injecting rats induced arthritis model of joint pain and swelling of inflammation reaction significant inhibition.Acute toxicity tests showed that: Tongfeng particles,the amount of 36 g / day is safe.Gout is a further observation of particles clinical efficacy and safety of drugs,special particles in the clinical study of gout,for Tongfeng particles lay the foundation for further development and application.MethodsAll patients in this study were collected from Wuhan City 2007.5-2007.11 Chinese medicine rheumatology patients,a total of 80 cases,the selected cases are in line with the "new Chinese medicine treatment of gout clinical study of the guiding principles" of the diagnostic criteria and Western medicine Mengzhaoheng edited by "gout" in acute gouty arthritis diagnostic criteria.A randomized controlled trial programme,according 1:1 the proportion of the study were randomly assigned to the experimental group and control group,and 40 cases,the control group of 40 patients.The test group to be Tongfeng particles:10g / time,3 times / day,0.5-1h before eating,dissolving internal temperature water(from Wuhan City Chinese medicine pharmacy Room,10 g per bag,and E-word system (2001),BZ05 - 037),the control group Maronites be bromine / Lijiali cents:50 mg / day,before meals served(Yichang Yangtze River Pharmaceutical Co.,Ltd.products, specifications:the country Luezhunzi H20040348).Two groups of patients for medication,a treatment for 7 days,a total of two cycles.Observation of two weeks before and after treatment with conventional erythrocyte sedimentation rate and blood, liver function and renal function changes,and recorded before and after treatment degree of abnormal joints integral changes.Statistical data,draw conclusions.ResultsThe total efficiency of 97.5%is better than 95%of the control group. Tongfeng particles can reduce serum uric acid in the blood,erythrocyte sedimentation rate,improve patient joint function,reduce arthritis symptoms,and no significant side effects and adverse reactions.ConclusionTongfeng particles of acute gouty arthritis there is a genuine effect,did not find any side effects and adverse reactions,Tongfeng particles to maintain the efficiency of traditional Chinese medicine decoction,acute gouty arthritis with obesity,diabetes,hypertension,diseases such as hyperlipidemia have some therapeutic effect,it is for clinical use.