Heat Lishi Huoxue Method To The Treatment Of Acute Gouty Arthritis Clinical Research

Background:With the change of lifestyle, gout, the ancient "Kings’Disease " has become "the king of diseases".1-2%of adults in the world suffer from the disease, which is one of the most common infectious arthritis in men. The onset of gout is concerned with factors such as gender, age, region and race, hyperuricemia, drugs, overweight, eating and drinking, genetics, metabolic syndrome, mental factors and so on. There is no cure to gouty arthritis, and drugs for acute gout involve colchicine. non-steroidal anti-inflammatory drugs, glucocorticoids and so on. Although these drugs take curative effect very fast, its side effect is significant, which needs the clinician to be more careful when choosing, considering the patient’s tolerance and compliance. Syndrome in TCM of acute gout is stagnation of damp-heat. Doctor Wang thought TCM treatment for acute gout is heat-clearing-dampness-removing and blood-circulation-promoting therapy, which has less side effects, and the curative effect in clinic.Objective:The objectives of this research are to observe clinical efficacy of traditional Chinese medicine Heat-Clearing-Dampness-Removing and Blood-Circulation-Promoting Therapy and non-steroidal anti-inflammatory drug treatment of western medicine on acute gouty arthritis, to explore whether the curative effect of TCM can match NSAIDs or not, which provide effective methods and evidence for traditional Chinese medicine to take into clinical practice.Methods:64outpatients were selected from Rheumatism Department of WangJing Hospital of China Academy of Chinese Medical Science. After diagnosis of acute gout which TCM syndrome is stagnation of damp-heat, patients were randomly divided into TCM treatment group and NSAIDs control group. On equivalent conditions of non-drug treatment, treatment group were given heat-clearing-dampness-removing and blood-circulation-promoting therapy and control group were given NSAIDs both for one week. Before and after treatment, data include TCM syndrome score, VAS score and biochemical indexes including serum uric acid, c-reactive protein, erythrocyte sedimentation rate.side effect were observed and statistically analyzed by statistical software SPSS16.0to evaluate curative effect.Results:(1)Before treatment, VAS score of two groups had no significant difference,P>0.05; after treatment.VAS score of both groups have significant improvement than before,P<0.05; however after treatment.there was no significant difference between the two groups,P>0.05.(2)before treatment.SUA, CRP, ESR had no significant difference between the two groups, P>0.05:after treatment.SUA, CRP, ESR of both groups have significant improvement than before.P<0.05;after treatment.SUA, CRP of treatment group had obviously better improvement than control group,however,there was no significant difference in the improvement of ESR.(3)After treatment,TCM syndrome score had significant improvement than before:the improvement of treatment group was obviously better than control group.P<0.05.(4) Effect time(pain released by20%)of control group was shorter than treatment group;(5)Treatment group which had fewer side effects was safer than control group.(6)Total effect rate of treatment group was93.75%,while control group was90.63%:there was no significant difference between the two groups.P>0.05.Conclusion:The curative effect in treatment of acute gouty arthritis was similar between heat-clearing-dampness-removing and blood-circulation-promoting therapy and NSAIDs; the latter took effect faster than the former:however, the former which could not only reduce serum uric acid level but also restrain the acute inflammation had few side effects is worth of clinical application.