Liver Temperature Only The Chatter Jiaoxiang Treatment Of Parkinson Disease Clinical And Experimental Research

Based on Prof.Zhang Qi's clinical experiences in diagnosis and treatment of deficiency syndrome of the Liver-Yang,clinical and experimental researches on cases with deficiency syndrome of Lver-Yand of Parkinson have been profoundly and sgstematically taked about in the essay.It is pointed out that the infected area of the disease is in the brainwhile its origin is in the Liver.Now a new argument has been firstly put forward n PD's deficiency synderome of LiverOYang,which should be treated by warming the Liver and relieving the depressed qi and promoting blood circulation.Treatment with Wengan Zhichan Capsule has been given and systematic clinical reserches have been made in 16 cases with PD.It is for the first time that the unified rating scale for parkinsonism(UPDS) and clinical global impression(CGI) have been applien in our country,which shouw that although Wengan Zhichan Capsule (WGZC) has the same curative effects as Xining(carbidopa and levodopa)on senile tremor of CTM and the assay of UPDS.The improvement of deficiency syndrome of Liver-Yang and physical signs with CGI is obviously superior to that of the control group,Xining Group.In order to clarify the curative effects of the rotation mechanism of PD,the wirter has applied PD's behavior medicine,neurotransmitter and biochemical treatment,etc,and has observed the experime-nts showing the effects upon rat's rotational behavior caused by 6-OHDA and the affect on DA in the brain of model rats with Yang deficiency caused by hydrocontisone,antioxi-dation,clearance of free redicals and control of MAL-B activity in the brain.The result shows that Wengan Zhichan Capsule has the action of receptor stimulant or postsynapse.The capsule can obviously increase the content of DA in the brain of model rats with Yang deficiency due to hydrocontis-one.It has the action of increase SOD in the reduced blood cells,CAT and GSH-PX activity in the brain of senile mice and can also reduce the information of MDA in blood plasma and liporuscin,obviously restrain MAO-B in the brain of senile mice.As compared with the control group,there is no difference.The capsule used in combination and phenol-phthaleinum tablet have the function of increasing enteric peristalsis ofmise.To sum up,its mechanism and therapeutic effects funcrion at least through antioxidation,clearance of free radicals and control of MAO-B activity in the brain, thus redcing DA oxidation and protecting DA neuron. All mention above has provided the reliable experimental facts for clinical application of the medicine,Wengan Zhichan Capsule.