Metabolic Syndrome And The Relationship Of The Sympathetic Nervous System And Chinese Medicine Observation, The Efficacy Of The Metabolic Syndrome

Objective:The metabolic syndrome(MS).which represents the clustering of metabolic risk factors,has no clear mechanisms at present.Studies performed in the past have shown that several of the components of the MS are associated with indirect and direct markers of sympathetic nervous overdrive,so some scholars indicate that there is a common pathogenetic background to connect the components of the MS in the sympathetic nervous system(SNS) activation.The aim of this study was designed to investigate the relationship between the metabolic syndrome(MS) in elderly and the SNS activity and to explore the possible mechanisms of the SNS activity.Methods:Seventy subjects were divided into three groups:normal control(NC) group(n=20),central obesity group(n=20) and MS group(n=30).Height, weight,waist circumference(WC),hip circumference,blood pressure,heart rate (HR),fasting plasma glucose(FPG),lipid-profile and uric acid(UA) were measured.Body mass index(BMI) and waist-to-hipratio(WHR) were calculated.And the plasma of each subject was collected,and the concentration of leptin,insulin,angiotensinâ…¡and norepinephrine were measured at the same time,and time domain of HRV were detected.comparing the heart rate, norepinephrine(NE),heart rate variability(HRV) in three groups to investigate the relationship between the MS in elderly and SNS activity and analyzing the association between SNS activity and each composition of MS, leptin,insulin,angiotensinâ…¡to explore the possible mechanisms of the SNS activity.The statistical data were analyzed by SPSS13.0 software.Results:1.The weight,BMI,WC,hip circumference,WHR,systolic blood pressure(SBP) and triglyceride(TG) in MS group were higher than those in NC group(P<0.05 or P<0.01),and the levels of high-density lipoprotein cholesterol(HDL-C) were lower(P<0.05).As compared with central obesity group,the WHR,SBP and TG were higher(P<0.05 or P<0.01) and the levels of HDL-C were lower(P<0.01) in MS group.The weight,WC,and hip circumference were higher in central obesity than those in NC group(P<0.05),while there was no significant difference in other parameters(P>0.05).2.The levels of NE were higher significantly in MS group than those in NC group(P<0.01),and comparing with central obesity group,the levels of NE were aslo higher,but there was no significant.The SDNN,SDANN,RMSSD and PNN50 were lower in MS grounp than those in NC group(P<0.01).the SDNN and SDANN were lower in MS group than those in central obesity,and there was a significant difference(P<0.05 or P<0.01).The SDNN,SDANN,RMSSD and PNN50 were lower in MS group than those in central obesity group,while there was no significant difference(P>0.05).3.The levels of leptin in MS group and central obesity group were increased than those in NC group(P<0.05 or P<0.01),and that in MS group were the highest and there was significant difference between MS group and central obesity(P<0.05).The levels of insulin in MS group and central obesity group were significantly increased than those in NC group(P<0.01).The levels of insulin in MS group were the highest and there was no significant difference between MS group and central obesity(P>0.05).The levels of Angâ…¡were higher in MS group than those in central obesity group and NC group(P<0.05 or P<0.01),and that in central oesity group were higher than NC group,while there was no significant difference(P>0.05).4.The Pearson correlation analysis revealed that the weight,BMI,WC, hip circumference,leptin,insulin and Angâ…¡positively correlated with the NE(P<0.05 or P<0.01),while the SDNN and SDANN negatively correlated with NE(P<0.01),and the weight,BMI,WC,hip circumference,WHR,TG,UA,leptin, insulin,Angâ…¡,and NE negatively correlated with the SDANN(P<0.05 or P<0.01),while the HDL-C and SDNN positively correlated with SDANN(P<0.05 or P<0.01). 5.Multiple linear regress analysis showed that the NE and the SDANN had perfectly correlated,and the independent factors of influence in SDANN were the leptin(P<0.05) and Angâ…¡(P<0.01).Conclusions:The SNS activity was significantly increased in the old man with MS.The weight,BMI,WC,hip circumference,abnormal lipid metabolism, leptin,insulin and Anglican all impact the SNS activity,while leptin and Angâ…¡were the main factors of the SNS activity.Therefore,this study provided a theoretical evidence for the therapeutic approach to the MS,and sympathoinhibition should be regared as an important versatile goal.This can be acheieved by the lifestyle changes,especially controling the body weight. Objective:To explore the curative effect observation of ginkgo biliba extract(GBE) on metabolic syndrome(MS) in the elderly man. Methods:60 patients suffered from MS which was in line with the International Diabetes Federation(IDF) diagnostic criteria were divided into 2 groups:the basis treatment group(A group,n=30)and the basis treatment coupled with GBE group(B group,n=30),the 20ml GBE was added into normal sodium,intravenous drip infusion 14 days,once daily pausing 5 days,and continuing 14 days.the body weight,BMI,waist circumference,hip circumference,WHR,SBP,DBP,FPG,PG 2h,HbAIc,TC,TG,LDL-C,HDL-C were measured before and after treatment. Results:After treatment,the waist circumference,WHR,SBP,PG 2h,HbAIc, TC,LDL-C in A group had significantly decreased compared with pre-treatment,the differences were significant(P<0.05);the WC,SBP,DBP, HbAIc,TC,TG in B group were significantly lower than those before treatment, the level of HDL-C was elevated(P<0.05).Inter-group comparison showed that:there was no significant differnce between two groups in the reduction of WC and TG(P>0.05).The effect of B group was superior in reducing HbAIc than that of A group.Conclusions:The basis treatment combined with GBE had unique advantages in degrading HbAIc,and obviously reduced TG,increased HDL-C.