| Background: Gastrointestinal cancer (esophageal cancer, gastric cancer, colorectal cancer) is our country, one of the most common malignant tumor, Because of its higher prevalence, prognosis is poor, people are seriously endangering the health of major diseases. At present, through endoscopy, gas double-contrast barium enema, B-mode ultrasonography, CT, MR examination can be found in space-occupying lesions of the digestive system. Together with such as endoscopic biopsy for pathological examination confirmed the cancer is often referred to as a means of payment target. Under normal circumstances, the adoption of fiber endoscopic biopsy from living tissue, the vast majority are in the advanced cancer. As for the precancerous lesions and early detection of latent cancer is difficult must exist, If at this time with the determination of tumor markers are often satisfied with the results can be achieved. Tumor markers, including a variety of active substances, such as various types of hormones, enzymes, specific and non-specific proteins, metabolites, and tumor cell proliferation and decay, such as material, General can be proteins, enzymes, glycolipids and glycoproteins, polyamines, such as hormones and gene classification.Chinese medicine to recognize the cause of gastrointestinal tumor has three: One that isSix exogenous one that is nothing more than wind, cold, heat, wet, dry, fire and other exogenous ones . Two that is Seven internal injuries, including diet, personal inappropriate, overwork, fear,Concerned sad and so scared. Three that is insufficiency of qi may be physical, disease, age and other factors. And from the above due to various causes of "Qi stagnation" "blood-stasls""TAN- Obstructive""Poison"" insufficiency of Qi" and so is the occurrence and development of tumor pathologyIn short, the tumor markers of joint detection, the individual can greatly make up for the gastrointestinal tract-specific tumor markers, the disadvantage is low sensitivity, Gastrointestinal improve early tumor detection rate, can be used to evaluate the clinical efficacy, prognosis. With syndrome differentiation of relations, but also the provision of clinical diagnosis and giving of treatment must help, and there is probably for the standardization of TCM Syndrome Differentiation of malignant tumor treatment to quantify the specific target. Purpose: In order to explore Gastric precancerous lesions and the TCM Syndrome and tumor invasion and metastasis of the relationship between the inner and further explore the nature of content of certification .Method: By summing up the past literature, summarized in syndrome differentiation based on clinical reality, the results of study will be used to gastric cancer and precancerous lesions in the patients . By two or more qualified physicians attending in patients detailed records and differentiation with relevant information and general information. By pathological analysis, to explore the pathological classification of gastric cancer the relationship between evidence-based; by immunohistochemical detection of gastric cancer patients with various card-based division of tumor-associated gene expression, the judge between the various card-type gastric cancer and tumor invasion differences in the transfer of preference.Results and Conclusion: Transfer of tumor gene expression and gastric cancer the relationship between TCM Syndrome study shows that: 1) the expression of gastric cancer-related genes were as follows: in the normal control group, precancerous lesions of, gastric cancer in three kinds of lesions, TFF1 positive expression rate of 100%, 78.3%, 37.04%, respectively, the trend was gradually weakened. 2 group and normal group were significantly different, (P<0.01); and EGFR in the normal group, precancerous lesions, gastric cancer were 26.67%, 46.3%, 74%, showing a gradual increase in the trend. Conclusion: The results showed that TFF1 and EGFR were negatively correlated (r= -0.913, P<0.01). value of MDV and EGFR was positively correlated with (r =0.936,P<0.01).2) Different card types have differences in gene expression, the initial results show that TCM syndrome type and pathological relevant part, such as 1) TFF1: hepatogastric not no difference with the control group (P>0.05), Type of condensation dampness compared with the control group P>0.01 but P<0.05, all TCM Syndrome-type group were significantly lower than the conttol group (P<0.01).compared with others hepatogastric not type, dampness condensation type, the spleen and stomach is no difference between the cold-type (P>0.05), drug resistance-type blood, Yin-insufficiency due to stomach-heat, blood type double deficit is no difference between (P>0.05), Hepatogastric not type, type of condensation dampness, cold spleen and blood type and drug resistance-type, Yin-insufficiency due to stomach-heat, blood type between the two-loss difference(P<0.05).2 ) EGFR: Type of the TCM group compared with the normal group are differences in ((P <0.05), Each group do not compare hepatogastric type condensation dampness type, the spleen and stomach cold type, blood type drug resistance, Yin-insufficiency due to stomach-heat no difference between negative-type (P> 0.05), Dual blood loss and there is difference between type (P <0.05); 3) MDV: the TCM syndrome group compared with the normal group were significantly different ((P <0. 01), was gradually increased density trend. Hepatogastric does not compare with the blood type and two-loss difference between type (P <0.05), not hepatogastric type condensation dampness type, the spleen and stomach cold type, blood type drug resistance, Yin-insufficiency due to stomach-heat no difference between type (P> 0.05), Condensation dampness type, the spleen and stomach cold type, blood type drug resistance, Yin-insufficiency due to stomach-heat, blood type double deficit is no difference between (P> 0.05). Prompted TCM with gastric cancer and precancerous lesions probably exist between the correlation... |
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