Relationship Between Matrix Metalloproteinase-1 Gene Polymorphism And Myocardial Infarction Incidence

Myocardial Infarction(MI) refers to a disease of heart muscle ischemic necrosis.Because of the coronary atherosclerosis atherosclerotic lesion,blood supply of aeteria coronaria may sharply decrease or break off, then cardiac muscle acute ischemia severely and lastingly leading to heart muscle necrosis.The persons who suffer from the disease are usually more than 50 years old with cerebral arteriosclerosis.it has become a great danger to human health with it's high morbidity and mortality as a kind of multifactor disease that includes environmental and genetic factors.in recent years.reserches have been made in the new field on the potential influence of gene polymorphism and gene mutation on cerebral infarction.it is believd that gene structure and expression abnormality,including mutation,shifting,inserting and lacking of the gene may be the basic reasons for cerebral infarction.this paper makes a research on the relationship between MMP-1(Matmetalloproteinase-1) and cerebral infarction,especially on genetic polymorphism in MMP-1 promoter(-1607 (GG/G)å'Œ-519 (A/G)) to make clear whether it is a dangerous genetic factor of cerebral infarction.objective To investigate the relationship between Polymorphism of the Matrix Metalloproteinase-1 Gene and the risk of Myocardial Infarction in ShanXi han population.methods a total of 68 patients with MI and 43 healthy adults diagnosed by coronary angiography were genotyped by polymerase chain reaction-restriction fragment length polymorphism for the -1607GG/G and -519A/G polymorphism in MMP1 gene.Result The frequency of -1607GG/G genetaye was significantly higher in patients with MI than that in controls[47.1% via 27.9% OR=1.67 p<0.001].People carrying GG allele had increased risk for MI[OR=1.78 p<0.001]. The frequency of -519A/G genetaye was significantly higher in patients with MI than that in controls[66.2% vs. 41.8% OR=1.58 p<0.001].People carrying A allele had increased risk for MI[OR=1.83 p<0.001].Conclusion Our data shows MMP1 gene -1607GG/G and -519A/G polymorphism is associated with the risk of MI , carring -1607GG and -519A alleles are more suspeptible for MI in ShanXi han population. The linkage disequilibrium may be attributed to the cause and the progress of MI...