Proof Of Evidence To The Contrary Side Measured And Abnormal Glucose Metabolism, Metabolic Syndrome Rats Tcm Syndrome Type Of Studies

Purpose:Through the experiment of establishing a stable successful merger sugar decompensate rat model,the metabolic syndrome and take their proofs are analyzed and the metabolic syndrome,adjust sugar rats damage of TCM syndromes type for clinical syndrome.Material and method:1.Experimental animals:Wistar male rats of clean grade were 65,6 weeks of age, body weight 180±20g,from Liaoning University of Traditional Chinese Medicine Center for animal experiments.Animals qualified No.:2004-0018 Liao is moving.2.Experimental diet:standard rat food,from Liaoning University of Traditional Chinese Medicine Center for animal experiments.Model of feed consumption by 7%of lard,sugar 10%,5%salt,cholesterol 1%,1%sodium taurocholate,egg yolk powder 6%,and the remaining 70 percent from general feed processing.Drinking water for the concentration of 20%sucrose water.3.Drugs:The experiment pharmacognostic Pieces purchased in Liaoning University of Traditional Chinese Medicine Affiliated Hospital outpatient pharmacy. Application of the four classical side Dachaihu Decoction(Golden Chamber), Huanglian Wendan Decoction(six due to be identified),zhibaidihaung(medical side test),Xuefuzhuyu Decoction(Lin Medical error).More than four prescriptions are expert consensus obtained prescriptions.4.Model and packetTo 65 rats to normal diet feeding adaptation in two weeks,using random number table 10 randomly selected as normal control group,the remaining model in rats given high-fat high-sugar diet that is high-salt diet and drinking water use 20%sucrose water.Model after the end of selected standards in line with the mode into a rat, using randomized controlled table method according to blood glucose levels were randomly divided into five sections,namely:the model group(8),on the 1st side group(9),on the 2nd side group(9),on-the 3rd party group(9),on the 4th side group(8).Results:1.Model success:sharing model 54 rats,according to model success criteria, from low blood sugar,weight,blood pressure does not target and removed 11, into a mold a total of 43 rats,the rate of 79.5 percent into mode.2.Comparison of body weight:12 and 15 weeks,each group with the normal weight control group were significantly higher(P＜0.01),1-4 Recipe group compared with the model group there were no significant differences in body weight(P＞0.05)3.Comparison of blood pressure:12 and 15 weeks,each group with normal blood pressure control group were significantly higher(P＜0.01),1-4 Recipe group compared with the model group there were no significant differences in blood pressure(P＞0.05)4.Comparison of glucose 1-side on the 4th group compared with the model group glucose levels no significant change(P＞0.05),all groups compared with normal control group glucose levels were significantly different(P＜0.01).5.Lipids comparison:No.1,2,4 side group compared with the model group triglyceride levels decreased significantly(respectively P＜0.05,P＜0.01), On the 2nd side group compared with the model group of high-density lipoprotein level was significantly increased(P＜0.05),each group with the normal control group was significantly higher triglyceride levels(P＜0.01),in addition to side on the 2nd group,the remaining group of high-density lipoprotein levels decreased significantly(P＜0.05,P＜0.01).6.1-4 side group compared with the model group of insulin and HOMA-IR index were significantly lower(P＜0.01),1 Recipe group and normal control group,no difference between insulin levels(P＞0.05),the remaining group and normal control group of insulin and HOMA-IR index were significantly higher(P＜0.05, P＜0.01). Conclusion:1.Application of high-fat high-sugar,high-salt diet with sucrose drinking water can set up a successful merger of abnormal glucose metabolism in rat model of MS.2.To determine for this experiment and abnormal glucose metabolism in rat MS evaluation criteria.3.The merger of abnormal glucose metabolism in rats with metabolic syndrome may exist hepatogastric smothery card,heat Phlegm card,hot Sheng certification deficiency and blood stasis Mailuoning card.And there is probably a mixture of each other,exist simultaneously.4.After three weeks of intervention,Dachaihu soup,Huanglian Wendan soup,soup Xuefuzhuyu can significantly reduce triglycerides.Huanglian Wendan Decoction can significantly reduce the level of high density lipoprotein.Dachaihu Decoction,Huanglian Wendan Decoction,Zhibai Dihaung,Xuefuzhuyu Decoction can significantly reduce insulin levels.But all the prescriptions for weight,blood pressure and blood glucose did not improve.