The Applications Of The Derivativeβ-cyclodextrin In Drug Delivery

β-cyclodextrin (P-CD) is cyclic non-reducing oligosaccharides with truncated cylindrical molecular shapes and is composed of seven glucopyranose units. The outsieds is hydrophilic, whereas the cavities is hydrophobic. Due to the particaler conformation,β-CD is able to enclose various kinds of drug, leading to changes in the physicochemical properties and stability and bioavailability of drug. The stability of the inclusion complex formed depends on the fit between the compound and the cavity ofβ-CD. The hydroxyl groups of theβ-CD are available as starting points for the structural modification. Various functional groups have been incorporated intoβ-CD to change both the polarity have been used to changes the property of the complexes. The derivatization ofβ-CD showed their potential for applications to drug delivery.The aim of paper was to sutdy the in vitro drug release properties of the modified P-CD. This thesis consists of the following three parts:1 Preparation and drug release property of P-cyclodextrin polymer composite membranes. The purpose of this paper was to investigate the in vitro drug release of cefazolin sodium (CZS). The composite membrane were prepared by Pβ-CD, Collagen and Polyvinylalcohol(PVA). The composite and Pβ-CD were characterized by FTIR. The influences of the PP-CD content on drug release property of CZS were investigated. The results showed that the retention capacity of drug on the membranes was dependent on the amount of Pβ-CD. The composite membranes that adsorbed CZS and allowed sustain release. The release properties of CZS showed the potential for applied clinical research.2 The Preparation of glycine modified P-cyclodextrin composite membranes for drug Sustained release. The glycine modified P-CD was preparated by 6-OTs-β-CD as intermediate. Glycine was a innocuous amino acids. And the derivativeβ-CD was solubility. The effect of adsorption time and property for drug release were studied. And the adsoption concent is optimal when the T=48h, C=0.4mg/mL. The optimal adsoption of the membranes were used to investigate the drug release properties.The result showed that the membranes were fitting for of drug release material.3 The modification of hydroxyapatite withβ-cyclodextrin for drug release. Hydroxyapatite (HAP) was modified byβ-CD, with the KH-560 as coupling reagent in order to increase the adsorption capacity of drug. The adsorption and in vitro release of anti-inflammatory drugs (Ofloxacin) on the products is investigated. The HAP and HAP-β-CD structure was characterized by FTIR spectroscopy. The results showed that:HAP-β-CD adsorption capacity of Ofloxacin was 14.5mg/g. The drug release is a uniform continuous process, and the sustained release last more than 10 hours, indicating that the drug through the HAP-β-CD release could be a promising long-term drug release system. The release profiles were fitted by Bhaskar equation and the first-order equation, the fitting data primarily follow the experimental results.