Pock Ren Pills, Jichuan Fried Side Treatment Of Slow Transit Constipation Theoretical And Experimental Research

Slow transit constipation is that due to lack of colonic motility and weakened peristalsis. The main symptoms are:Stool frequency is reduced, the number of bowel movements less than 2 or 3 times per week, abdominal distension, stool show a mass or induration, there is not the sense of defecation, reduction of bowel sounds.Patients with longer duration, often with varying degrees of tension and anxiety.In the treatment, mainly symptomatic treatment of modern medicine, many drugs to be used, effect unstable, drug resistance, such as unreasonable drug use may cause black lesions of the colon, increase constipation, and even dehydration, electrolyte imbalance and other side effects; surgical treatment may cause injuries, its effect imprecise, postoperative complications. Chinese medicine treat slow transit constipation with the whole concept as a guide,It develop individualized treatment programs with the patients,the Chinese medical herbs with good effect, low toxicity, low cost advantage, combined with the application of modern medical treatment, often obtain satisfactory effect.This subject systematically summarize the pathology and treatment of Chinese and Western medicine,observe Hemp Seed Pill,Ferry Brew treatment outcomes of the rats with slow transit constipation, and to explore its mechanism preliminarily.First,Literature ReviewFirstly, slow transit constipation pathogenesis and treatment is systematically summarized with traditional Chinese Medicine. Second, the modern medical understanding and treatment of etiology and pathology is summarized. Finally, Hemp Seed Pill,Ferry Brew's modern clinical and experimental research are summarized, both provide a better reference for clinical application.Second,The theoretical partThere is Dryness bind for the Pathogenesis of slow transit constipation, the syndrome is dry intestinal constipation.Yang heat dryness bind needs to be moistened and precipitated, thus Hemp Seed Pill is used.While Yang deficiency dryness bind needs to be moistened and warmed, thus Ferry Brew is used.Insufficient body fluid is its common pathogenesis, it reflects both the common moisten treatment, but warm and cold, yin and yang contrast clever.This section systematically summarizes the clearing, warming treatment of slow transit constipation, moreover, the decoction and syndrome essence, distinction of difficulty, the core of the drug and the similar decoction identification are described in detail.Third, experimental study3.1 ObjectiveIn-depth study of Hemp Seed Pill,Ferry Brew, this provide experimental evidence for the clearing, warming treatment of slow transit constipation and offer experimental support for TCM clinical treatment of slow transit constipation.3.2 MethodsUsing phenol ester compound tablet fed rat model of slow transit constipation, research Hemp Seed Pill,Ferry Brew treatment mechanism of slow transit constipation.Rats were divided into normal space, model control, Hemp Seed Pill group, Ferry Brew group. After the modeling, the conventional treatment group are given drugs, The normal space group and model control group are given equal amount of tap water accordingly.End of the experiment, colonic myoelectric determination of slow wave amplitude, the amplitude coefficient of variation (%) and rat slow wave frequency, coefficient of variation (%) of the change;Using RT-PCR method to detect colon of c-kit mRNA expression. Radioimmunoassay of rat colon tissue content of neurotransmitters SP and VIP.3.3 Results(1) Hemp Seed Pill,Ferry Brew group both increase slow wave amplitude in rats, in which Ferry Brew compared with the model group differences (P<0.05), Hemp Seed Pill group and model group, no difference. Coefficient of variation of slow wave amplitude, frequency and frequency variation, there were no differences between the groups.(2) Hemp Seed Pill,Ferry Brew group SP are higher than in model group, which Ferry Brew compared with the model group differences (P<0.05), Hemp Seed Pill group and model group, no difference. Hemp Seed Pill VIP content is lower than the model group, Ferry Brew VIP group is higher than the model group, both groups have no difference with the model.(3) Hemp Seed Pill,Ferry Brew group compared with the model group, c-kit gene expression is no different, in which Hemp Seed Pill group c-kit gene expression level higher than the model group, while the Ferry Brew group is lower than the model group.3.4 Conclusion(1) Hemp Seed Pill,Ferry Brew group can both improve slow-wave amplitude in rats, in which Ferry Brew compared with the model group differences (P<0.05), Hemp Seed Pill group and model group without difference. Ferry Brew represent the treatment of warming and moistening, It works by adjusting constipation gastrointestinal myoelectric.(2) Hemp Seed Pill,Ferry Brew can both improve the content of SP, and Ferry Brew compared with the model group differences (P<0.05), illustrating the two treatment groups can excite SP, increase colonic motility and play the role of treating slow transit constipation.(3) Hemp Seed Pill,Ferry Brew group compared with the model group, c-kit gene expression did not differ significantly,the two don't work by adjusting the expression of c-kit gene expression, This needs to be further studied later.