Flow-mediated Vasodilation In Detection Of Type 2 Diabetes Brachial Artery Endothelial Function

Objective:1.To study the changes in endothelium-dependent vasodilatation in the different developmental phases of Type 2 diabetes.2. To study blood lipids in diabetic patients with brachial artery endothelium-dependent relaxation of the relations, and provide strong clinical evidence of diabetes diagnosis, treatment and prognosis of tips and assessment.Methods:Methods:To select 76 case:divided it into healthy control group 30 (â… )Simple group of 24 cases of diabetes mellitus (â…¡)and 22 cases of diabetes with high-fat group (â…¢)Dynamic observation brachial artery, brachial artery diameter was measured by FMD detection technology witch underlaying echo-tracking(ET) without wound,before and after reactive hyperemia(RH), calculate the percent change in brachial artery diameter(FMD) induced by reactive hyperemia,to reflect its endothelial function indirectlyResults:1. Research study among the 3 groups general information and experimental results: Diabetic patient's age, sex, BMI, blood glucose, heart rate and blood pressure control group no significant difference among the 3 groups. (P>0.05)2. Three groups of blood lipid and reactive hyperemia vasodilation of brachial artery diameter comparison:Diabetic group and control group, the basis of the brachial artery diameter, blood filling the situation was no significant difference (P>0.05). Two groups of diabetic patients FMD were significantly lower than the control group (P<0.01). Diabetes associated with high cholesterol group was significantly lower than pure diabetic group, FMD (P<0.05).Conclusions:1. Patients with diabetes have impaired vascular endothelial function, such changes appear in the bloodstream before the filling of damage, indicating disorder of glucose metabolism leading to increased endothelial dysfunction and an important factor2. Diabetes associated with impaired endothelial function in patients with high blood lipids is more serious and that high blood cholesterol and the degree of endothelial dysfunction, or in itself is a major factor leading to endothelial injury. Therefore, not only for early stage patients with diabetes blood glucose, but also for lipid intervention is necessary.3. FMD can be changes in vascular endothelial function in early and objective evaluation of endothelium-dependent vasodilatation.