| Purpose:This study aims to observe the animal experiments Centella asiatica extract solution in the rabbit cornea scar treatment of the role of Centella asiatica in ophthalmology to provide experimental basis for clinical application.Material and method: To take 30 rabbits (60 eyes),with burning method produced an animal model of corneal scar were randomly divided into 3 groups: A group of physiological saline solution control group (20 eyes); B group 1% Centella asiatica extract solution the treatment group (20 eyes); C group 0.2% sodium hyaluronate solution of the control group (20 eyes). 60 days after the random number table method were used to observe the changes of rabbit corneal scar, combined with structural changes in pathology and light microscopy.Results:1. Centella asiatica extract solution group after treatment, corneal scar size, thickness and sodium hyaluronate group and physiological saline solution significantly reduced compared with the control group, there is a significant difference (P<0.05).2. Histopathology showed asiatica extract solution group corneal stroma fibroblasts arrangement of sodium hyaluronate compared with the control group and physiological saline control group rules.Conclusion:1.Centella asiatica extract solution on rabbit corneal scar reducing effect is significant.2. Centella asiatica extract solution can effectively inhibit collagen formation of cell proliferation and collagen synthesis, is an effective drug for the treatment of corneal scars. |
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