Five Internal Organs Yu, Ea Co-stimulatory Molecules Of Cd80 Ean Rabbits Cd86mrna Protein Response Level Research

Objective: To observe the rising moon by electric needle bladder the five Zang一organ Yu of Guillain-Barre syndrome (GBS) classic animal model of one acute allergic neuritis (EAN) in rabbits costimulatory molecules CD80, CD86mRNA protein response level of the impact study costimulatory molecules in the pathogenesis of EAN and thus reveals the bladder skin by electro-acupuncture treatment of EAN Yu the five Zang一organ efficacy mechanism for "governing Flaccidity Yu was given the five internal organs" theory to provide experimental basis.Experimental Methods: 12ml extract of bovine myelin basic proteinⅡ12ml plus complete Freund's adjuvant (CFA), shaken by test-tube oscillators, and fully prepared mixture of immune rabbit animal model of EAN. 80 shared experimental rabbits, divided into four groups, one of 20 normal, healthy rabbits for the blank control group, blank group P2 with 12ml normal saline to replace the same amount of complete Freund's adjuvant (CFA) for immunization as a control, another check successful model 60 EAN rabbits were randomly divided into model group, EA group, immunoglobulin group, 20 in each group. Electro-acupuncture group were given electro-acupuncture treatment of the bladder by the five internal organs Yu; immune balls eggs.Results: Compared with model group compared to the blank group costimulatory molecules CD80 expression levels at the beginning of increased incidence of early to reach the highest peak (p <0.01), the expression level after treatment significantly decreased (p <0.05), No. 14 day electro-acupuncture group compared with the immune globulin group had no significant difference (p> 0.05); compared with the blank model group costimulatory molecules CD86 expression levels at the acute phase the lowest (p <0.01), after treatment the expression levels or high (p <0.05), the first 14 days electro-acupuncture group compared with the immune globulin group had no significant difference (p>0.05).Conclusion: The costimulatory molecules CD80, CD86 involved in the pathogenesis of EAN increase the role of CD80 immune; CD86 has a downward effect on the immune. Electric needle bladder hazy Yu treatment by the five internal organs can costimulatory molecules CD80 significantly reduced the level of protein expression, CD86 protein expression level increased.