Rapid Oxidation Reaction In The Micro Reactor, And The Low Temperature Lithium Halogen Exchange Reaction

Chapter 1:As a new type of organic synthesis methods, micro reactor technology has received lots of attentions from both the academic and industrial viewpoints. Micro reactor is sort of pipe line reactor with diameter from 10 to 1000μm. Compared with conventional macroscale batch reactors, it exhibit numerous practical advantages, including safety, easy modulation, and easy scale up for industrial production. In this chapter, the development and application of micro reactor was reviewed.Chapter 2:Along with the further promotion of micro reactor application, more and more organic reaction types were introduced in. According to the different reaction type and conditions, all sorts of types were created by research workers to meet different needs. In this chapter, materials, drives and potential application devices of micro reactor were introduced, and current fabrication of micro reactor were compared.Chapter 3:An efficient procedure of benzylic compounds oxidation was described, which is facile, economical and environmentally friendly. The oxidation can be accomplished in a good yield within 10 seconds at room temperature. A new synthetic method in microreactor to synthesize carbonyl compounds which tolerates various substrates is developed. Compared with the conventional method, good to excellent yields have been obtained within a very short reaction time.Chapter 4:Micro reactors also enable the precise control of reactive intermediates and thereby facilitate highly selective reactions which difficult to achieve in conventional reactors. The Li-Br exchange reaction in micro reactor at low temperature were studied. And the micro reactor was used to control the active intermediates. Using our micro reactor, a really good performance in Li-Br exchange reaction can be achieved.