Study Of Microwave Synthesis, Biologically Active And Crystalline Structure 2-Aryloxymethylbenzimidazoles Derivatives

This thesis includes three chapters.Chapter 1: A brief review for the new research of benzimidazole derivaties. This chapter is a brief review for the research, synthetic methods and application values of benzimidazole derivaties recent years.Chapter 2: Microwave synthesis crystal structure and biology activity of 1- propionitrile (propionic acid) -2-aryloxymethylbenzimidazole derivatives A simple, rapid, and highly efficient method has been developed for the aze-Michael addition of 2-aryl-oxymethylbenzimidazole derivatives in the presence of anhydrous potassium carbonate under microwave irradiation. A series of 1-propionitrile (propionic acid)-2-aryloxymethylbenzimidazole derivatives have been prepared and characterized by 1H NMR, 13C NMR, IR spectra and elemental analysis.The crystal of 4e has shown the intra molecular forces. Crystal data: triclinic, a =10.413(3) ?, b = 15.927(4) ?, c = 9.951(3) ? , 90°, 111.007(15)°= 90°, V1540.7(7) ?3, D x 1.390 Mg/m3, Z 4, F(000) 672, 0.099 mm-1, R0.0752, w R 0.1226, space group P1/n. The preliminary biological activity tests show that all the compounds have obvious regulating activities for the growth of the rape.Chapter 3: Synthesis, crystal structure and Biological Activities of 5-(2-Aryloxymethylbenzimidazole-1-ethylidene)-1H-Tetrazols DerivativesA series of new 5-(2-aryloxymethylbenzimidazole-1-ethylidene) -1H -tetrazols were synthesized by Aza-Michael Addition of 2-[(un)substituted phenoxymethyl] benzimidazole- 1-cyanoethyl. The structures of all synthesized compounds were confirmed by IR, 1H NMR, 13C NMR spectra and elemental analysis. In the crystal of 5f, the compound was assembled to a three-dimensional supramolecular structure by the intermolecular hydrogen bonds and - interactions. Crystal data: triclinic, space group P1/n, a = 7.2977(10) ? , b = 10.8855(15) ?, c = 10.9993(15) ?, 100.039(2) , 93.036(2) = 97.959(2) , V 849.4(2) ?3, Dx 1.428 Mg/m 3,Z 2, F(000) 380, 0.103 mm 1, R 0.0413, w R 0.0857. The preliminary biological activity tests show that most of the title compounds have obvious regulating activities for the growth of the rape.