| Zinc, which is the second most abundant transition metal ion in human body after iron, plays an important role in cytobiology and cytotroph. Meanwhile, it's known to us that zinc has taken a share in synthesis of enzyme, structure and function of proteins, even in cellular metabolism and nerve conduction process. The disorder of zinc metabolism would lead to dysfunction of organism and initiate some sever diseases such as Alzheimer's, ischemic stroke and infantile diarrhea. Due to the high sensitivity and short responsive time of fluorescence detector, fluorescent sensor is gradually concerned and to be effective method to monitor or detect relevant species such as cations, anions. The fluorescent sensors based on zinc(II) are the derivates of 8-aminoquinoline (5-AQ) and di(2-picolylamine) coded as DPA, which contains a motif like diaminoethane similar to EDTA. In order to distinguish zinc(Ⅱ) rapidly, we have designed three target molecules whose structures are very concise.All of the three target molecules are effective fluorescent sensors of zinc(Ⅱ). The target molecule MT (4-methyl-2-(pyridine-2-yl)thiazle) shows special enhancement of fluorescence intensity while zinc(Ⅱ) was added, this unique spectra performance is reciprocal when the other selected ions were added.It's interesting that the target molecule BTT (4-(3-methylbenzo[b] thiophen-2-yl)-2-(pyridin-2-yl)thiazole) and MTT (4-methyl-2-(pyridin-2-yl)-5-(thiophen-2-yl)thiazole)shows similar ratiometric fluorescent response to zinc(Ⅱ). After addition of zinc(Ⅱ), the original emission peak decrease gradually and new emission bands appears. |
PDF Full Text Request