Methodology Research Of One-pot Synthesis Of Symmetrically Azetidine Connected With S-S Bond And Naphthofuran Derivatives

This paper mainly consists of two parts:The first part: synthesis of symmetrically azetidine connected with S-S bond via copper-catalyzed multi-component reaction. Multi-component reaction also called "one-pot" reaction, which three or more raw materials in the reaction, with multi-steps approach and ultimately produce a target product, which contains all main starting compounds fragments . Multi-component reaction compared with the general reaction has its unique advantages: atom economy,environmental friendliness, one step form many chemical bonds, and simple operation. Multi-component have become a significant part of today's organic synthesis. More and more organic and pharmaceutical chemists pay attention to Multi-component reactions. Based on Our research group's previous studies. The first chapter of our works focuses on the development of One-step synthesis of symmetrically azetidine connected with S-S bond. Research shows that: CuI-catalyzed synthesis of multi-component reaction is simple operation, high selectivity, easy separation of products and can be used under mild conditions. we provide a simple and efficient way for the systhesis of four-membered heterocyclic connected with S-S bond. The second part: Synthesis Research of naphthofuran derivatives catalytic by small organic molecules(DMAP). Organocatalysts have got great development in recent years due to their unique advantages, such as environment-friendly, stable, inexpensive, more readily available and being used under hydrous or aerobic reaction conditions. The second chapter is the naphthofuran derivatives was obtained by performing the one pot reaction of the 2-hydroxy-1-naphthaldehyde or 1-(2-hydroxynap-hthalen-1-yl)ethanone and 2-bromo-1-phenylethan-one cata-lyzed by 4 - dimethylaminopyridine (DMAP). And a series of naphthafuran derivatives are synthesized. The reaction for the synthesis of naphthofuran derivatives via DMAP-catalyzed shows highly effective, simple reaction conditions and easy product separation. We offer a new and efficient way for the synthesis of naphthofuran derivatives.