Sorafenib Synthesis Process

Sorafenib is a new type multi-kinase inhibitor which used for the treatment advanced renal cell carcinoma.In this paper, the process of sorfenib is researched from 2-picolinic acid as raw material via 5 steps such as acylation, chlorination, amidation, etherification, condensation, the overall yield is 75.2% and the purity is 99.6%. These processes are easy operation, lower cost and less of pollution. The synthesis process of [4-(4-Aminophenoxy) (2-pyridyl)]-N-methylcarboxam was researched which use of the room-temperature ionic liquid [BMIM] [BF4] as solvent (instead of DMA). It is a clean synthesis process. The product yield is 89.0%, the purity is 98.9%. And in mixed solvents, the intermediates 4-Chloro-3-(trifluoromethyl) phenyl isocyanate was prepared from p-Chlorobenzotrifluoride which was transformed into the corresponding isocyanate by mixed acid nitration, catalytic hydrogenation, isocyanat. The total yield of three steps is 87.1%,purity is 97.7%.The structures of inter-mediate and production are confirmed by IR, 1H-NMR.